Literature DB >> 1612738

Immunoglobulin G2 confers protection against Borrelia burgdorferi infection in LSH hamsters.

J L Schmitz1, R F Schell, S M Callister, S D Lovrich, S P Day, J E Coe.   

Abstract

We showed that immune serum and its immunoglobulin fractions, specifically immunoglobulin G2 (IgG2), could confer complete protection to irradiated hamsters challenged with the Lyme disease spirochete. Immune serum and its immunoglobulin fractions also killed Borrelia burgdorferi in vitro. Depletion of complement in vivo abrogated the ability of IgG2 to confer complete protection against B. burgdorferi. Furthermore, the majority of antibody reactivity directed against B. burgdorferi was found in the IgG2 fraction. These findings demonstrate that IgG2 plays an important role in acquired resistance against infection with B. burgdorferi. Additional studies are needed to determine the mechanism(s) by which B. burgdorferi evades host defenses despite the development of an effective borreliacidal antibody response.

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Year:  1992        PMID： 1612738      PMCID： PMC257220          DOI： 10.1128/iai.60.7.2677-2682.1992

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  26 in total

1.  Protection of mice against the Lyme disease agent by immunizing with recombinant OspA.

Authors:  E Fikrig; S W Barthold; F S Kantor; R A Flavell
Journal:  Science       Date:  1990-10-26       Impact factor: 47.728

2.  Characterization of the protective antibody response to Borrelia burgdorferi in experimentally infected LSH hamsters.

Authors:  J L Schmitz; R F Schell; S D Lovrich; S M Callister; J E Coe
Journal:  Infect Immun       Date:  1991-06       Impact factor: 3.441

3.  Histopathology of Lyme arthritis in LSH hamsters.

Authors:  A Hejka; J L Schmitz; D M England; S M Callister; R F Schell
Journal:  Am J Pathol       Date:  1989-05       Impact factor: 4.307

4.  The immune response in the hamster. II. Studies on IgM.

Authors:  J E Coe
Journal:  Immunology       Date:  1970-02       Impact factor: 7.397

5.  Experimental infection of the hamster with Borrelia burgdorferi.

Authors:  R C Johnson; C Kodner; M Russell; P H Duray
Journal:  Ann N Y Acad Sci       Date:  1988       Impact factor: 5.691

6.  Antibody response in white-footed mice (Peromyscus leucopus) experimentally infected with the Lyme disease spirochete (Borrelia burgdorferi).

Authors:  T G Schwan; K K Kime; M E Schrumpf; J E Coe; W J Simpson
Journal:  Infect Immun       Date:  1989-11       Impact factor: 3.441

7.  Role of immunoglobulin G in killing of Borrelia burgdorferi by the classical complement pathway.

Authors:  S K Kochi; R C Johnson
Journal:  Infect Immun       Date:  1988-02       Impact factor: 3.441

8.  Induction of lyme arthritis in LSH hamsters.

Authors:  J L Schmitz; R F Schell; A Hejka; D M England; L Konick
Journal:  Infect Immun       Date:  1988-09       Impact factor: 3.441

9.  Borreliacidal activity of sera from hamsters infected with the Lyme disease spirochete.

Authors:  S D Lovrich; S M Callister; J L Schmitz; J D Alder; R F Schell
Journal:  Infect Immun       Date:  1991-08       Impact factor: 3.441

Review 10.  Complement and the host's defense against the pneumococcus.

Authors:  J A Winkelstein
Journal:  Crit Rev Microbiol       Date:  1984       Impact factor: 7.624
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  10 in total

1.  Major histocompatibility complex class II-independent generation of neutralizing antibodies against T-cell-dependent Borrelia burgdorferi antigens presented by dendritic cells: regulation by NK and gammadelta T cells.

Authors:  M L Mbow; N Zeidner; R D Gilmore; M Dolan; J Piesman; R G Titus
Journal:  Infect Immun       Date:  2001-04       Impact factor: 3.441

2.  Involvement of CD4+ T lymphocytes in induction of severe destructive Lyme arthritis in inbred LSH hamsters.

Authors:  L C Lim; D M England; N J Glowacki; B K DuChateau; R F Schell
Journal:  Infect Immun       Date:  1995-12       Impact factor: 3.441

3.  Ability of canine Lyme disease vaccine to protect hamsters against infection with several isolates of Borrelia burgdorferi.

Authors:  D A Jobe; S M Callister; L C Lim; S D Lovrich; R F Schell
Journal:  J Clin Microbiol       Date:  1994-03       Impact factor: 5.948

4.  Transfer of antibody against Borrelia duttonii from mother to young in ddY mice.

Authors:  M G Morshed; M Yokota; T Nakazawa; H Konishi
Journal:  Infect Immun       Date:  1993-10       Impact factor: 3.441

5.  Seroprotective groups among isolates of Borrelia burgdorferi.

Authors:  S D Lovrich; S M Callister; L C Lim; R F Schell
Journal:  Infect Immun       Date:  1993-10       Impact factor: 3.441

6.  Passive immunizing activity of sera from mice infected with Borrelia burgdorferi.

Authors:  S W Barthold; L K Bockenstedt
Journal:  Infect Immun       Date:  1993-11       Impact factor: 3.441

7.  Protection of C3H/HeN mice from challenge with Borrelia burgdorferi through active immunization with OspA, OspB, or OspC, but not with OspD or the 83-kilodalton antigen.

Authors:  W S Probert; R B LeFebvre
Journal:  Infect Immun       Date:  1994-05       Impact factor: 3.441

8.  Borrelia burgdorferi-specific T lymphocytes induce severe destructive Lyme arthritis.

Authors:  L C Lim; D M England; B K DuChateau; N J Glowacki; R F Schell
Journal:  Infect Immun       Date:  1995-04       Impact factor: 3.441

9.  Abilities of OspA proteins from different seroprotective groups of Borrelia burgdorferi to protect hamsters from infection.

Authors:  S D Lovrich; S M Callister; B K DuChateau; L C Lim; J Winfrey; S P Day; R F Schell
Journal:  Infect Immun       Date:  1995-06       Impact factor: 3.441

10.  Single exposure of mice to Borrelia burgdorferi elicits immunoglobulin G antibodies characteristic of secondary immune response without production of interleukin-4 by immune T cells.

Authors:  A B Frey; T D Rao
Journal:  Infect Immun       Date:  1995-07       Impact factor: 3.441
  10 in total

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