Literature DB >> 16125648

Downhill protein folding: evolution meets physics.

Martin Gruebele1.   

Abstract

Proteins can be redesigned to fold downhill on a free energy surface characterized by only a few coordinates, confirming a principal prediction of the 'energy-landscape' model. Nonetheless, natural proteins have small but significant barriers. Spectroscopy and kinetics reveal potential biological causes for activation barriers during protein folding: evolution against protein aggregation and for protein function.

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Year:  2005        PMID： 16125648     DOI： 10.1016/j.crvi.2005.02.007

Source DB:  PubMed          Journal:  C R Biol        ISSN： 1631-0691            Impact factor:   1.583


  43 in total

Review 1.  Knot theory in understanding proteins.

Authors:  Rama Mishra; Shantha Bhushan
Journal:  J Math Biol       Date:  2011-11-22       Impact factor: 2.259

2.  The origin of nonmonotonic complex behavior and the effects of nonnative interactions on the diffusive properties of protein folding.

Authors:  Ronaldo J Oliveira; Paul C Whitford; Jorge Chahine; Jin Wang; José N Onuchic; Vitor B P Leite
Journal:  Biophys J       Date:  2010-07-21       Impact factor: 4.033

3.  Folding simulations of a de novo designed protein with a betaalphabeta fold.

Authors:  Yifei Qi; Yongqi Huang; Huanhuan Liang; Zhirong Liu; Luhua Lai
Journal:  Biophys J       Date:  2010-01-20       Impact factor: 4.033

4.  Analytical biochemistry: Weighing up protein folding.

Authors:  Martin Gruebele
Journal:  Nature       Date:  2010-12-02       Impact factor: 49.962

5.  Strand swapping regulates the iron-sulfur cluster in the diabetes drug target mitoNEET.

Authors:  Elizabeth Leigh Baxter; Patricia A Jennings; José N Onuchic
Journal:  Proc Natl Acad Sci U S A       Date:  2012-01-23       Impact factor: 11.205

6.  A natural missing link between activated and downhill protein folding scenarios.

Authors:  Feng Liu; Caroline Maynard; Gregory Scott; Artem Melnykov; Kathleen B Hall; Martin Gruebele
Journal:  Phys Chem Chem Phys       Date:  2010-02-11       Impact factor: 3.676

Review 7.  Protein folding thermodynamics and dynamics: where physics, chemistry, and biology meet.

Authors:  Eugene Shakhnovich
Journal:  Chem Rev       Date:  2006-05       Impact factor: 60.622

8.  DNA folding and melting observed in real time redefine the energy landscape.

Authors:  Hairong Ma; Chaozhi Wan; Aiguo Wu; Ahmed H Zewail
Journal:  Proc Natl Acad Sci U S A       Date:  2007-01-10       Impact factor: 11.205

9.  Protein folding is slaved to solvent motions.

Authors:  H Frauenfelder; P W Fenimore; G Chen; B H McMahon
Journal:  Proc Natl Acad Sci U S A       Date:  2006-10-09       Impact factor: 11.205

10.  Solvent-tuning the collapse and helix formation time scales of lambda(6-85)*.

Authors:  Charles Dumont; Yoshitaka Matsumura; Seung Joong Kim; Jinsong Li; Elena Kondrashkina; Hiroshi Kihara; Martin Gruebele
Journal:  Protein Sci       Date:  2006-11       Impact factor: 6.725
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