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Literature DB >> 16121476

Vitamin D for the prevention of preeclampsia? A hypothesis.

Abstract

Preeclampsia has been suggested to result from a partial breakdown of tolerance to the developing fetus after maternal immune maladaptation. Several of the proposed immunomodulatory properties of the hormonal vitamin D system could potentially have beneficial effects for successful maintenance of pregnancy. Preeclampsia is characterized by marked changes in vitamin D metabolism. This paper reviews the evidence suggesting that the immunomodulatory properties of 1,25(OH)2D may play a key role in maintaining immunological tolerance in pregnancy, and proposes that ensuring adequate vitamin D status/intake may help in the prevention and management of preeclampsia.

Entities: Chemical

Mesh：

Substances：
Vitamin D

Year: 2005 PMID： 16121476 DOI： 10.1301/nr.2005.jul.225-232

Source DB: PubMed Journal: Nutr Rev ISSN： 0029-6643 Impact factor: 7.110

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Cited

24 in total

Review 1. Extrarenal expression of the 25-hydroxyvitamin D-1-hydroxylase.

Authors: J S Adams; M Hewison
Journal: Arch Biochem Biophys Date: 2012-03-14 Impact factor: 4.013

2. Proteome differences in the first- and third-trimester human placentas.

Authors: Behrouz Gharesi-Fard; Jaleh Zolghadri; Eskandar Kamali-Sarvestani
Journal: Reprod Sci Date: 2014-09-08 Impact factor: 3.060

Review 3. Vitamin D effects on pregnancy and the placenta.

Authors: J S Shin; M Y Choi; M S Longtine; D M Nelson
Journal: Placenta Date: 2010-09-22 Impact factor: 3.481

Review 4. Vitamin D may be a link to black-white disparities in adverse birth outcomes.

Authors: Lisa M Bodnar; Hyagriv N Simhan
Journal: Obstet Gynecol Surv Date: 2010-04 Impact factor: 2.347

5. A nested case-control study of first-trimester maternal vitamin D status and risk for spontaneous preterm birth.

Authors: Arthur M Baker; Sina Haeri; Carlos A Camargo; Alison M Stuebe; Kim A Boggess
Journal: Am J Perinatol Date: 2011-04-15 Impact factor: 1.862

6. Vitamin D Supplementation Suppresses Hypoxia-Stimulated Placental Cytokine Secretion, Hypertension and CD4⁺ T Cell Stimulation in Response to Placental Ischemia.

Authors: Marie M Darby; Kedra Wallace; Denise Cornelius; Krystal T Chatman; Janae N Mosely; James N Martin; Christine A Purser; Rodney C Baker; Michelle T Owens; B Babbette Lamarca
Journal: Med J Obstet Gynecol Date: 2013-09-23

Vitamin D for the prevention of preeclampsia? A hypothesis.

Review 1. Extrarenal expression of the 25-hydroxyvitamin D-1-hydroxylase.

2. Proteome differences in the first- and third-trimester human placentas.

Review 3. Vitamin D effects on pregnancy and the placenta.

Review 4. Vitamin D may be a link to black-white disparities in adverse birth outcomes.

5. A nested case-control study of first-trimester maternal vitamin D status and risk for spontaneous preterm birth.

6. Vitamin D Supplementation Suppresses Hypoxia-Stimulated Placental Cytokine Secretion, Hypertension and CD4⁺ T Cell Stimulation in Response to Placental Ischemia.

7. Analyzing adherence to prenatal supplement: does pill count measure up?

8. Association between vitamin D deficiency and primary cesarean section.

9. Maternal vitamin D deficiency increases the risk of preeclampsia.

10. Dietary supplements contribute substantially to the total nutrient intake in pregnant Norwegian women.