OBJECTIVE: Our purpose is to describe methods of assessing leakiness of the blood-brain barrier and explain mechanisms for exploiting the blood-brain barrier for therapeutic purposes. CONCLUSION: Knowledge of the workings of the blood-brain barrier is important for an understanding of the ways in which blood-brain barrier permeability may be used as a surrogate marker for drug therapeutic response. Manipulation of the blood-brain barrier may provide a means for selectively targeting tumors for drug delivery.
OBJECTIVE: Our purpose is to describe methods of assessing leakiness of the blood-brain barrier and explain mechanisms for exploiting the blood-brain barrier for therapeutic purposes. CONCLUSION: Knowledge of the workings of the blood-brain barrier is important for an understanding of the ways in which blood-brain barrier permeability may be used as a surrogate marker for drug therapeutic response. Manipulation of the blood-brain barrier may provide a means for selectively targeting tumors for drug delivery.
Authors: Vera C Keil; Bogdan Pintea; Gerrit H Gielen; Susanne Greschus; Rolf Fimmers; Jürgen Gieseke; Matthias Simon; Hans H Schild; Dariusch R Hadizadeh Journal: J Neurooncol Date: 2017-04-19 Impact factor: 4.130
Authors: Daniela B Almeida-Freitas; Marco C Pinho; Maria C G Otaduy; Henrique F Braga; Daniel Meira-Freitas; Claudia da Costa Leite Journal: Neuroradiology Date: 2014-03-21 Impact factor: 2.804
Authors: M Azuma; Z A Khant; M Kitajima; H Uetani; T Watanabe; K Yokogami; H Takeshima; T Hirai Journal: AJNR Am J Neuroradiol Date: 2019-12-19 Impact factor: 3.825
Authors: R Jain; S K Ellika; L Scarpace; L R Schultz; J P Rock; J Gutierrez; S C Patel; J Ewing; T Mikkelsen Journal: AJNR Am J Neuroradiol Date: 2008-01-17 Impact factor: 3.825