Literature DB >> 16115608

Regulation of cyclooxygenase catalysis by hydroperoxides.

Richard J Kulmacz1.   

Abstract

Activation of cyclooxygenase catalysis in prostaglandin H synthase-1 and -2 by peroxide-dependent formation of a tyrosyl radical is emerging as an important part of regulating cellular production of bioactive prostanoids. This review discusses the mechanism of tyrosyl radical formation and the influence of peroxide, fatty acid, peroxidase cosubstrate, and protein structure on the activation process and cyclooxygenase catalysis.

Entities:  

Mesh：

Substances：

Year:  2005        PMID： 16115608     DOI： 10.1016/j.bbrc.2005.08.030

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  12 in total

Review 1.  Enzymes of the cyclooxygenase pathways of prostanoid biosynthesis.

Authors:  William L Smith; Yoshihiro Urade; Per-Johan Jakobsson
Journal:  Chem Rev       Date:  2011-09-27       Impact factor: 60.622

2.  Interaction between head and neck squamous cell carcinoma cells and fibroblasts in the biosynthesis of PGE2.

Authors:  Sonia Alcolea; Rosa Antón; Mercedes Camacho; Marta Soler; Arantzazu Alfranca; Francesc-Xavier Avilés-Jurado; Juan-Miguel Redondo; Miquel Quer; Xavier León; Luis Vila
Journal:  J Lipid Res       Date:  2012-02-04       Impact factor: 5.922

3.  Inducible COX-2 dominates over COX-1 in prostacyclin biosynthesis: mechanisms of COX-2 inhibitor risk to heart disease.

Authors:  Cheng-Huai Ruan; Shui-Ping So; Ke-He Ruan
Journal:  Life Sci       Date:  2010-10-28       Impact factor: 5.037

Review 4.  Selenoproteins in colon cancer.

Authors:  Kristin M Peters; Bradley A Carlson; Vadim N Gladyshev; Petra A Tsuji
Journal:  Free Radic Biol Med       Date:  2018-05-22       Impact factor: 7.376

Review 5.  Heme enzyme structure and function.

Authors:  Thomas L Poulos
Journal:  Chem Rev       Date:  2014-01-08       Impact factor: 60.622

6.  Polymorphic human prostaglandin H synthase-2 proteins and their interactions with cyclooxygenase substrates and inhibitors.

Authors:  W Liu; E M Poole; C M Ulrich; R J Kulmacz
Journal:  Pharmacogenomics J       Date:  2010-06-15       Impact factor: 3.550

7.  Structural basis of fatty acid substrate binding to cyclooxygenase-2.

Authors:  Alex J Vecchio; Danielle M Simmons; Michael G Malkowski
Journal:  J Biol Chem       Date:  2010-05-12       Impact factor: 5.157

Review 8.  Cyclooxygenases: structural and functional insights.

Authors:  Carol A Rouzer; Lawrence J Marnett
Journal:  J Lipid Res       Date:  2008-10-23       Impact factor: 5.922

Review 9.  Prostaglandin H synthase: resolved and unresolved mechanistic issues.

Authors:  Ah-Lim Tsai; Richard J Kulmacz
Journal:  Arch Biochem Biophys       Date:  2009-09-01       Impact factor: 4.013

10.  Autocatalytic nitration of prostaglandin endoperoxide synthase-2 by nitrite inhibits prostanoid formation in rat alveolar macrophages.

Authors:  Stefan Schildknecht; Christiaan Karreman; Andreas Daiber; Cheng Zhao; Jürg Hamacher; David Perlman; Birgit Jung; Bernd van der Loo; Peter O'Connor; Marcel Leist; Volker Ullrich; Markus Michael Bachschmid
Journal:  Antioxid Redox Signal       Date:  2012-06-25       Impact factor: 8.401
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.