Literature DB >> 16114488

Lipoxygenase inhibitory constituents from Indigofera oblongifolia.

Ahsan Sharif1, Ejaz Ahmed, Abdul Malik, Naheed Riaz, Nighat Afza, Sarfraz Ahmad Nawaz, Muhammad Arshad, Muhammad Raza Shah, Muhammad Iqbal Choudhary.   

Abstract

Indigin, alkylated xanthene (1) and indigoferic acid (2) have been isolated from the chloroform soluble fraction of Indigofera oblongifolia, along with beta-sitosterol (3) and 3-hydroxybenzoic acid (4), which are reported for the first time from this species. Their structures were determined through spectroscopic techniques. Both the new compounds 1 and 2 showed significant activity against enzyme lipoxygenase, while 2 further showed moderate inhibition against BChE.

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Year:  2005        PMID： 16114488     DOI： 10.1007/BF02977339

Source DB:  PubMed          Journal:  Arch Pharm Res        ISSN： 0253-6269            Impact factor:   4.946


  7 in total

1.  5,7-Dihy-droxy-3,6-dimeth-oxy-2-(4-meth-oxy-phen-yl)-4H-chromen-4-one monohydrate.

Authors:  Akhtar Mohammad; Itrat Anis; Vickie McKee; Josef W A Frese; Muhammad Raza Shah
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-10-02

2.  Indigofera oblongifolia Prevents Lead Acetate-Induced Hepatotoxicity, Oxidative Stress, Fibrosis and Apoptosis in Rats.

Authors:  Ahmed E Abdel Moneim
Journal:  PLoS One       Date:  2016-07-08       Impact factor: 3.240

3.  Neuroprotective potential of Indigofera oblongifolia leaf methanolic extract against lead acetate-induced neurotoxicity.

Authors:  Saleh Al-Quraishy; Mohamed A Dkhil; Shaimaa R Ibrahim; Ahmed E Abdel Moneim
Journal:  Neural Regen Res       Date:  2016-11       Impact factor: 5.135

4.  Density functional theory, molecular docking and bioassay studies on (S)-2-hydroxy-N-(2S,3S,4R,E)-1,3,4 trihydroxyicos-16-en-2-yl)tricosanamide.

Authors:  Taj Ur Rahman; Muhammad Aurang Zeb; De-Bing Pu; Wajiha Liaqat; Khurshid Ayub; Wei-Lie Xiao; Tariq Mahmood; Muhammad Sajid; Riaz Hussain
Journal:  Heliyon       Date:  2019-08-02

5.  Indigofera oblongifolia mitigates lead-acetate-induced kidney damage and apoptosis in a rat model.

Authors:  Mohamed A Dkhil; Mohamed S Al-Khalifa; Saleh Al-Quraishy; Rafat Zrieq; Ahmed Esmat Abdel Moneim
Journal:  Drug Des Devel Ther       Date:  2016-06-02       Impact factor: 4.162

6.  Effect of Indigofera oblongifolia on the Hepatic Oxidative Status and Expression of Inflammatory and Apoptotic Genes during Blood-Stage Murine Malaria.

Authors:  Mohamed A Dkhil; Esam M Al-Shaebi; Saleh Al-Quraishy
Journal:  Oxid Med Cell Longev       Date:  2019-01-29       Impact factor: 6.543

7.  Anthelmintic and antimicrobial activity of Indigofera oblongifolia leaf extracts.

Authors:  Mohamed A Dkhil; Rafat Zreiq; Taghreed A Hafiz; Murad A Mubaraki; Shadi Sulaiman; Fahad Algahtani; Rewaida Abdel-Gaber; Esam M Al-Shaebi; Saleh Al-Quraishy
Journal:  Saudi J Biol Sci       Date:  2019-12-02       Impact factor: 4.219
  7 in total

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