Diagnosis and management of patients with suspected acute myocardial infarction.

Patients admitted with suspected acute myocardial infarction (MI) constitute a diagnostic, prognostic and therapeutic challenge for the treating physician. Elevation of a marker of myocardial necrosis together with ischemic symptoms and/or ischemic ECG changes are mandatory for the diagnosis of acute MI. Troponin T or I is the preferred marker of myocardial necrosis. The diagnostic process should start as soon as possible. The introduction of prehospital ECG recordings and prehospital administration of thrombolytic treatment in case of ST-segment elevation MI, have been shown to decrease the time from onset of symptoms till treatment considerably, which also translates into saved lives. In contrast, data of the value of prehospital analyses of biochemical markers are still limited. In patients without ST-segment elevation on admission the diagnosis is dependent on repeated measurements of markers of myocardial damage, which together with other biochemical markers (e.g. CRP and BNP/NT-proBNP) also are useful for risk assessment. Patients identified to be at low risk of future cardiac events might be discharged early and, on the contrary, a more intense treatment might be started in patients identified to be at high risk. An elevated troponin concentration is shown to identify patients who benefit from antithrombotic therapy and invasive procedures. Several different risk scoring models based on a combination of clinical variables, ECG-changes and biochemical markers, have been shown to further improve risk assessment and selection of treatment.