Nancy Pearl Solomon1, Donald A Robin. 1. Army Audiology & Speech Center, Walter Reed Army Medical Center, Washington, DC 20307-5001, USA. nancy.p.solomon@us.army.mil
Abstract
BACKGROUND: Fatigue and the accompanying perception of effort are often heightened in Parkinson's disease. OBJECTIVES: To compare performance on three sense-of-effort tasks between patients with PD and matched neurologically normal control subjects. METHODS: Sixteen PD subjects and 16 normal subjects performed three tasks to assess sense of effort: self-ratings of effort using direct-magnitude estimation, generating pressures at various levels of effort, and sustaining a submaximal level of effort. The latter two tasks were done with handgrip and tongue elevation. RESULTS: Two of the three tasks successfully differentiated the groups. Subjects with PD provided significantly higher ratings of effort for general daily activities and for speech. During the constant-effort task, pressure curves decayed more rapidly for the PD subjects. CONCLUSIONS: Performance by PD subjects on the constant-effort task resembled that by normal adults who were pre-fatigued in previous experiments. Results support greater than normal sense-of-effort related to fatigue in PD, and provide preliminary validation of a performance-based physiologic task to assess abnormal sense of effort in this population.
BACKGROUND:Fatigue and the accompanying perception of effort are often heightened in Parkinson's disease. OBJECTIVES: To compare performance on three sense-of-effort tasks between patients with PD and matched neurologically normal control subjects. METHODS: Sixteen PD subjects and 16 normal subjects performed three tasks to assess sense of effort: self-ratings of effort using direct-magnitude estimation, generating pressures at various levels of effort, and sustaining a submaximal level of effort. The latter two tasks were done with handgrip and tongue elevation. RESULTS: Two of the three tasks successfully differentiated the groups. Subjects with PD provided significantly higher ratings of effort for general daily activities and for speech. During the constant-effort task, pressure curves decayed more rapidly for the PD subjects. CONCLUSIONS: Performance by PD subjects on the constant-effort task resembled that by normal adults who were pre-fatigued in previous experiments. Results support greater than normal sense-of-effort related to fatigue in PD, and provide preliminary validation of a performance-based physiologic task to assess abnormal sense of effort in this population.
Authors: L O Ramig; S Sapir; S Countryman; A A Pawlas; C O'Brien; M Hoehn; L L Thompson Journal: J Neurol Neurosurg Psychiatry Date: 2001-10 Impact factor: 10.154
Authors: Tatiana Witjas; E Kaphan; J P Azulay; O Blin; M Ceccaldi; J Pouget; M Poncet; A Ali Chérif Journal: Neurology Date: 2002-08-13 Impact factor: 9.910
Authors: Benzi M Kluger; Karen Herlofson; Kelvin L Chou; Jau-Shin Lou; Christopher G Goetz; Anthony E Lang; Daniel Weintraub; Joseph Friedman Journal: Mov Disord Date: 2016-02-16 Impact factor: 10.338
Authors: Joanne McCormack; Vincent Casey; Richard Conway; Jean Saunders; Alison Perry Journal: J Neuroeng Rehabil Date: 2015-03-24 Impact factor: 4.262
Authors: Joseph H Friedman; James C Beck; Kelvin L Chou; Gracia Clark; Christopher P Fagundes; Christopher G Goetz; Karen Herlofson; Benzi Kluger; Lauren B Krupp; Anthony E Lang; Jao-Shin Lou; Laura Marsh; Anne Newbould; Daniel Weintraub Journal: NPJ Parkinsons Dis Date: 2016-01-14