Yun-ting Zhang1, Chun-yan Zhang, Jing Zhang, Wei Li. 1. Department of Radiology, General Hospital, Tianjin Medical University, Tianjin 300052, China. cjr.zhangyunting@vip.163.com
Abstract
BACKGROUND: It is known that the brain structure changes with normal aging. The objective of this study was to quantify the anisotropy and average diffusion coefficient (DCavg) of the brain in normal adults to demonstrate the microstructure changes of brain with aging. METHODS: One hundred and six normal adults were examined with diffusion tensor imaging (DTI). The fractional anisotropy (FA), 1-volume ratio (1-VR), relative anisotropy (RA) and average diffusion coefficient (DCavg) of different anatomic sites of brain were measured, correlated with age and compared among three broad age groups. RESULTS: Except in lentiform nucleus, the anisotropy increased and DCavg decreased with aging. Both anisotropy and DCavg of lentiform nucleus increased with aging. The normal reference values of DTI parameters of normal Chinese adult in major anatomic sites were acquired. CONCLUSIONS: DTI data obtained noninvasively can reflect the microstructural changes with aging. The normal reference values acquired can serve as reference standards in differentiation of brain white matter diseases.
BACKGROUND: It is known that the brain structure changes with normal aging. The objective of this study was to quantify the anisotropy and average diffusion coefficient (DCavg) of the brain in normal adults to demonstrate the microstructure changes of brain with aging. METHODS: One hundred and six normal adults were examined with diffusion tensor imaging (DTI). The fractional anisotropy (FA), 1-volume ratio (1-VR), relative anisotropy (RA) and average diffusion coefficient (DCavg) of different anatomic sites of brain were measured, correlated with age and compared among three broad age groups. RESULTS: Except in lentiform nucleus, the anisotropy increased and DCavg decreased with aging. Both anisotropy and DCavg of lentiform nucleus increased with aging. The normal reference values of DTI parameters of normal Chinese adult in major anatomic sites were acquired. CONCLUSIONS: DTI data obtained noninvasively can reflect the microstructural changes with aging. The normal reference values acquired can serve as reference standards in differentiation of brain white matter diseases.
Authors: Qian Jun Yap; Irvin Teh; Paolo Fusar-Poli; Min Yi Sum; Carissa Kuswanto; Kang Sim Journal: J Neural Transm (Vienna) Date: 2013-01-18 Impact factor: 3.575
Authors: Lee Ryan; Katrin Walther; Barbara B Bendlin; Lih-Fen Lue; Douglas G Walker; Elizabeth L Glisky Journal: Neuroimage Date: 2010-09-06 Impact factor: 6.556
Authors: S Burgmans; M P J van Boxtel; E H B M Gronenschild; E F P M Vuurman; P Hofman; H B M Uylings; J Jolles; N Raz Journal: Neuroimage Date: 2009-10-19 Impact factor: 6.556
Authors: Annemieke J M H Verkerk; Rachel Schot; Belinda Dumee; Karlijn Schellekens; Sigrid Swagemakers; Aida M Bertoli-Avella; Maarten H Lequin; Jeroen Dudink; Paul Govaert; A L van Zwol; Jennifer Hirst; Marja W Wessels; Coriene Catsman-Berrevoets; Frans W Verheijen; Esther de Graaff; Irenaeus F M de Coo; Johan M Kros; Rob Willemsen; Patrick J Willems; Peter J van der Spek; Grazia M S Mancini Journal: Am J Hum Genet Date: 2009-06-25 Impact factor: 11.025