Predrag Ljubuncic1, Omar Abu-Salach, Arieh Bomzon. 1. Department of Pharmacology, Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Efron Street, PO Box 9649, Haifa 31096, Israel.
Abstract
AIM: To investigate the ability of ursodeoxycholic acid (UDCA) to scavenge superoxide anion (O(2)(-)). METHODS: We assessed the ability of UDCA to scavenge (O(2)(-)) generated by xanthine-xanthine oxidase (X-XO) in a cell-free system and its effect on the rate of O(2)(-)-induced ascorbic acid (AA) oxidation in hepatic post-mitochondrial supernatants. RESULTS: UDCA at a concentration as high as 1 mmol/L did not impair the ability of the X-XO system to generate O(2)(-), but could scavenge O(2)(-) at concentrations of 0.5 and 1 mmol/L, and decrease the rate of AA oxidation at a concentration of 100 micromol/L. CONCLUSION: UDCA can scavenge O(2)(-), an action that may be beneficial to patients with primary biliary cirrhosis.
AIM: To investigate the ability of ursodeoxycholic acid (UDCA) to scavenge superoxide anion (O(2)(-)). METHODS: We assessed the ability of UDCA to scavenge (O(2)(-)) generated by xanthine-xanthine oxidase (X-XO) in a cell-free system and its effect on the rate of O(2)(-)-induced ascorbic acid (AA) oxidation in hepatic post-mitochondrial supernatants. RESULTS:UDCA at a concentration as high as 1 mmol/L did not impair the ability of the X-XO system to generate O(2)(-), but could scavenge O(2)(-) at concentrations of 0.5 and 1 mmol/L, and decrease the rate of AA oxidation at a concentration of 100 micromol/L. CONCLUSION:UDCA can scavenge O(2)(-), an action that may be beneficial to patients with primary biliary cirrhosis.
Authors: Sui Peng; Xiaofang Huo; Davood Rezaei; Qiuyang Zhang; Xi Zhang; Chunhua Yu; Kiyotaka Asanuma; Edaire Cheng; Thai H Pham; David H Wang; Minhu Chen; Rhonda F Souza; Stuart Jon Spechler Journal: Am J Physiol Gastrointest Liver Physiol Date: 2014-05-22 Impact factor: 4.052
Authors: Michał J Sabat; Anna M Wiśniewska-Becker; Michał Markiewicz; Katarzyna M Marzec; Jakub Dybas; Justyna Furso; Paweł Pabisz; Mariusz Duda; Anna M Pawlak Journal: Membranes (Basel) Date: 2021-04-29