Susie K Lee1, Peter H R Green. 1. Celiac Disease Center, Columbia University College of Physicians, New York, New York, USA.
Abstract
PURPOSE OF REVIEW: The primary objective of this review is to highlight the evidence for the role of endoscopy in celiac disease. RECENT FINDINGS: Evidence is presented that the endoscopic markers of celiac disease are specific although not sensitive for the disease. Villous atrophy, the hallmark of celiac disease, is patchy in the duodenum, and various techniques may identify areas of villous atrophy. These methods include magnification endoscopy and chromoendoscopy. The most recent innovation, video capsule endoscopy, may be of value in the diagnosis of celiac disease and in the assessment of patients with complicated celiac disease. SUMMARY: Endoscopy and duodenal biopsies are the mainstay for diagnosing celiac disease. Although characteristic endoscopic features may be useful, their absence does not exclude celiac disease. Random biopsy, even of normal-appearing mucosa is necessary for the diagnosis of celiac disease.
PURPOSE OF REVIEW: The primary objective of this review is to highlight the evidence for the role of endoscopy in celiac disease. RECENT FINDINGS: Evidence is presented that the endoscopic markers of celiac disease are specific although not sensitive for the disease. Villous atrophy, the hallmark of celiac disease, is patchy in the duodenum, and various techniques may identify areas of villous atrophy. These methods include magnification endoscopy and chromoendoscopy. The most recent innovation, video capsule endoscopy, may be of value in the diagnosis of celiac disease and in the assessment of patients with complicated celiac disease. SUMMARY: Endoscopy and duodenal biopsies are the mainstay for diagnosing celiac disease. Although characteristic endoscopic features may be useful, their absence does not exclude celiac disease. Random biopsy, even of normal-appearing mucosa is necessary for the diagnosis of celiac disease.
Authors: Kassem Barada; Abbas Bitar; Mohamad Abdul-Razak Mokadem; Jana Ghazi Hashash; Peter Green Journal: World J Gastroenterol Date: 2010-03-28 Impact factor: 5.742
Authors: Joseph A Murray; Alberto Rubio-Tapia; Carol T Van Dyke; Deanna L Brogan; Mary A Knipschield; Brian Lahr; Ashwin Rumalla; Alan R Zinsmeister; Christopher J Gostout Journal: Clin Gastroenterol Hepatol Date: 2007-12-21 Impact factor: 11.382