Literature DB >> 16091222

Viral and cellular dynamics in HIV disease.

R Pat Bucy1.   

Abstract

The control mechanisms that maintain a steady state viral load during chronic HIV-1 infection are critical to understanding the pathophysiology of HIV disease. The conceptual features of the two alternative models of viral control, referred to in this article as target cell limitation and immune control, are compared to the data regarding the viral and cellular dynamics of HIV-1 infection and the pattern of changes induced by effective antiretroviral drug therapy. The available data support the model that an antigen-driven immune response is the primary mechanism that limits viral growth in vivo.

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Year:  2004        PMID： 16091222     DOI： 10.1007/s11904-004-0006-y

Source DB:  PubMed          Journal:  Curr HIV/AIDS Rep        ISSN： 1548-3568            Impact factor:   5.071


  51 in total

1.  Virus dynamics and drug therapy.

Authors:  S Bonhoeffer; R M May; G M Shaw; M A Nowak
Journal:  Proc Natl Acad Sci U S A       Date:  1997-06-24       Impact factor: 11.205

2.  Multiple modes of cellular activation and virus transmission in HIV infection: a role for chronically and latently infected cells in sustaining viral replication.

Authors:  Z Grossman; M B Feinberg; W E Paul
Journal:  Proc Natl Acad Sci U S A       Date:  1998-05-26       Impact factor: 11.205

3.  Rapid production and clearance of HIV-1 and hepatitis C virus assessed by large volume plasma apheresis.

Authors:  B Ramratnam; S Bonhoeffer; J Binley; A Hurley; L Zhang; J E Mittler; M Markowitz; J P Moore; A S Perelson; D D Ho
Journal:  Lancet       Date:  1999-11-20       Impact factor: 79.321

4.  Population dynamics of immune responses to persistent viruses.

Authors:  M A Nowak; C R Bangham
Journal:  Science       Date:  1996-04-05       Impact factor: 47.728

5.  Modeling plasma virus concentration during primary HIV infection.

Authors:  M A Stafford; L Corey; Y Cao; E S Daar; D D Ho; A S Perelson
Journal:  J Theor Biol       Date:  2000-04-07       Impact factor: 2.691

6.  An activated CD8+ lymphocyte appears in lymph nodes of rhesus monkeys early after infection with simian immunodeficiency virus.

Authors:  K A Reimann; G B Snyder; L V Chalifoux; B C Waite; M D Miller; H Yamamoto; O Spertini; N L Letvin
Journal:  J Clin Invest       Date:  1991-10       Impact factor: 14.808

7.  Reduction of HIV-1 in blood and lymph nodes following potent antiretroviral therapy and the virologic correlates of treatment failure.

Authors:  J K Wong; H F Günthard; D V Havlir; Z Q Zhang; A T Haase; C C Ignacio; S Kwok; E Emini; D D Richman
Journal:  Proc Natl Acad Sci U S A       Date:  1997-11-11       Impact factor: 11.205

8.  Viral and Cellular Dynamics in HIV Disease.

Authors:  R. Pat Bucy
Journal:  Curr Infect Dis Rep       Date:  2001-06       Impact factor: 3.725

9.  Increases in CD4 T lymphocytes with intermittent courses of interleukin-2 in patients with human immunodeficiency virus infection. A preliminary study.

Authors:  J A Kovacs; M Baseler; R J Dewar; S Vogel; R T Davey; J Falloon; M A Polis; R E Walker; R Stevens; N P Salzman; Lane H. Clifford
Journal:  N Engl J Med       Date:  1995-03-02       Impact factor: 91.245

10.  The repertoire of cytotoxic T lymphocytes in the recognition of mutant simian immunodeficiency virus variants.

Authors:  L Shen; Z W Chen; N L Letvin
Journal:  J Immunol       Date:  1994-12-15       Impact factor: 5.422
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