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Literature DB >> 11384561

Viral and Cellular Dynamics in HIV Disease.

Abstract

The control mechanisms that maintain a steady-state viral load during chronic HIV-1 infection are critical to understanding the pathophysiology of HIV disease. This paper compares the conceptual features of the two alternative models of viral control, target cell limitation and immune control, with available data on the viral and cellular dynamics of HIV-1 infection and the pattern of changes induced by effective antiretroviral drug therapy. These data suggest that an antigen-driven immune response is the primary control mechanism for in vivo viral growth.

Entities: Disease

Year: 2001 PMID： 11384561 DOI： 10.1007/s11908-001-0033-4

Source DB: PubMed Journal: Curr Infect Dis Rep ISSN： 1523-3847 Impact factor: 3.725

50 in total

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2 in total

Review 1. Viral and cellular dynamics in HIV disease.

Authors: R Pat Bucy
Journal: Curr HIV/AIDS Rep Date: 2004-04 Impact factor: 5.071

2. Comparison of immunologic assays for detecting immune responses in HIV immunotherapeutic studies: AIDS Clinical Trials Group Trial A5181.

Authors: Bernard J C Macatangay; Lu Zheng; Charles R Rinaldo; Alan L Landay; Richard B Pollard; Savita Pahwa; Michael M Lederman; R Pat Bucy
Journal: Clin Vaccine Immunol Date: 2010-07-14

2 in total