Literature DB >> 16087641

Total synthesis of scutellarin-7-O-glucuronide.

Jian-Mei Cui1, Gang Fang, Ya-Bo Duan, Qian Liu, Li-Ping Wu, Guo-Hong Zhang, Song Wu.   

Abstract

Scutellarin-7-O-glucuronide (1) has been synthesized from 2-hydroxyl-4,5,6-trimethoxyacetophenone through eight steps, including Michael addition, cyclization, hydrogenation, hydroxyl protection, deprotection, etc. The overall yield of 13% is much higher than that reported (0.6%) by L. Farkas, G. Mezey-Vàndor et al. in 1974.

Entities:  

Mesh:

Substances:

Year:  2005        PMID: 16087641     DOI: 10.1080/1028602032000169587

Source DB:  PubMed          Journal:  J Asian Nat Prod Res        ISSN: 1028-6020            Impact factor:   1.569


  3 in total

1.  Synthesis and bio-activity evaluation of scutellarein as a potent agent for the therapy of ischemic cerebrovascular disease.

Authors:  Li-Hua Qian; Nian-Guang Li; Yu-Ping Tang; Li Zhang; Hao Tang; Zhen-Jiang Wang; Li Liu; Shu-Lin Song; Jian-Ming Guo; An-Wei Ding
Journal:  Int J Mol Sci       Date:  2011-11-18       Impact factor: 5.923

2.  An Efficient Chemical Synthesis of Scutellarein: An in Vivo Metabolite of Scutellarin.

Authors:  Ze-Xi Dong; Nian-Guang Li; Peng-Xuan Zhang; Ting Gu; Wen-Yu Wu; Zhi-Hao Shi
Journal:  Molecules       Date:  2016-02-25       Impact factor: 4.411

3.  Synthesis and protective effect of scutellarein on focal cerebral ischemia/reperfusion in rats.

Authors:  Lihua Qian; Minzhe Shen; Hao Tang; Yuping Tang; Li Zhang; Yifan Fu; Qianping Shi; Nian-Guang Li
Journal:  Molecules       Date:  2012-09-06       Impact factor: 4.411

  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.