BACKGROUND: We sought to study the influence of pT classification, pN status, tumor volume, and number of lymph nodes invaded on survival of patients with head and neck cancers to improve therapeutic indications. METHODS: This was a retrospective study of 621 consecutive patients treated from 1990 to 1997 by a single team. RESULTS: In univariate analysis, pT classification (p < .0001), pN status (p < .0001), capsule rupture (p < .0001), the number of lymph nodes invaded (0, 1-3, 4-9, > or =10) (p < .0001), and the tumor volume (p < .0001) were significantly associated with overall survival. A Cox model identified as independent prognostic indicators age (p < .0001), pT classification (p < .0001), and pN status (p < .0001). CONCLUSIONS: Not only pT classification and pN status but also the number of the lymph nodes invaded and the tumor volume should be considered as essential prognostic indicators, and any clinical trial developed should stratify accordingly. (c) 2005 Wiley Periodicals, Inc.
BACKGROUND: We sought to study the influence of pT classification, pN status, tumor volume, and number of lymph nodes invaded on survival of patients with head and neck cancers to improve therapeutic indications. METHODS: This was a retrospective study of 621 consecutive patients treated from 1990 to 1997 by a single team. RESULTS: In univariate analysis, pT classification (p < .0001), pN status (p < .0001), capsule rupture (p < .0001), the number of lymph nodes invaded (0, 1-3, 4-9, > or =10) (p < .0001), and the tumor volume (p < .0001) were significantly associated with overall survival. A Cox model identified as independent prognostic indicators age (p < .0001), pT classification (p < .0001), and pN status (p < .0001). CONCLUSIONS: Not only pT classification and pN status but also the number of the lymph nodes invaded and the tumor volume should be considered as essential prognostic indicators, and any clinical trial developed should stratify accordingly. (c) 2005 Wiley Periodicals, Inc.
Authors: Benjamin H Lok; Jeremy Setton; Nicola Caria; Jonathan Romanyshyn; Suzanne L Wolden; Michael J Zelefsky; Jeffery Park; Nicholas Rowan; Eric J Sherman; Matthew G Fury; Alan Ho; David G Pfister; Richard J Wong; Jatin P Shah; Dennis H Kraus; Zhigang Zhang; Karen D Schupak; Daphna Y Gelblum; Shyam D Rao; Nancy Y Lee Journal: Int J Radiat Oncol Biol Phys Date: 2011-06-02 Impact factor: 7.038
Authors: C Ayoub; C Wasylyk; Y Li; E Thomas; L Marisa; A Robé; M Roux; J Abecassis; A de Reyniès; B Wasylyk Journal: Br J Cancer Date: 2010-07-27 Impact factor: 7.640
Authors: Denys J Loeffelbein; Michael Souvatzoglou; Veronika Wankerl; Julia Dinges; Lucas M Ritschl; Thomas Mücke; Anja Pickhard; Matthias Eiber; Markus Schwaiger; Ambros J Beer Journal: BMC Cancer Date: 2014-11-19 Impact factor: 4.430