Literature DB >> 15350212

Regulation of protein kinases; controlling activity through activation segment conformation.

Brad Nolen1, Susan Taylor, Gourisankar Ghosh.   

Abstract

There are currently at least forty-six unique protein kinase crystal structures, twenty-four of which are available in an active state. Here we examine these structures using a structural bioinformatics approach to understand how the conformation of the activation segment controls kinase activity. Copyright 2004 Cell Press

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Year:  2004        PMID： 15350212     DOI： 10.1016/j.molcel.2004.08.024

Source DB:  PubMed          Journal:  Mol Cell        ISSN： 1097-2765            Impact factor:   17.970


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