| Literature DB >> 16060386 |
Nobuhiro Koyama1, Tomoko Nagahiro, Yuichi Yamaguchi, Taichi Ohshiro, Rokuro Masuma, Hiroshi Tomoda, Satoshi Omura.
Abstract
During our screening for microbial inhibitors of lipid droplet accumulation in macrophages, a new compound designated spylidone was isolated along with two structurally related known compounds, PF1052 and vermisporin, from the fermentation broth of Phoma sp. FKI-1840 by solvent extraction, silica gel column chromatography, ODS column chromatography and preparative HPLC. From the structure elucidation, spylidone has a spiro ring containing 2,4-pyrrolidinedione. Among the three compounds, only spylidone was found to inhibit lipid droplet accumulation in macrophages at 10 to approximately 50 microM without any cytotoxic effect.Entities:
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Year: 2005 PMID： 16060386 DOI： 10.1038/ja.2005.42
Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649