Literature DB >> 16060172

Nonsteroidal anti-inflammatory drugs for rheumatoid arthritis during pregnancy.

Ana Florescu1, Gideon Koren.   

Abstract

QUESTION: I am treating two pregnant patients who have rheumatoid arthritis with nonsteroidal anti-inflammatory drugs. Are these medications safe at high doses during pregnancy? ANSWER: While these medications do not appear to increase overall rates of congenital malformations, they do increase the risk of ductus arteriosus constriction or closure.

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Year:  2005        PMID： 16060172      PMCID： PMC1479517     

Source DB:  PubMed          Journal:  Can Fam Physician        ISSN： 0008-350X            Impact factor:   3.275


  10 in total

Review 1.  Epidemiologic assessment of the safety of conventional nonsteroidal anti-inflammatory drugs.

Authors:  S Hernández-Díaz; L A García-Rodríguez
Journal:  Am J Med       Date:  2001-02-19       Impact factor: 4.965

2.  Nonsteroidal antiinflammatory drugs during third trimester and the risk of premature closure of the ductus arteriosus: a meta-analysis.

Authors:  Gideon Koren; Ana Florescu; Adriana Moldovan Costei; Radinka Boskovic; Myla E Moretti
Journal:  Ann Pharmacother       Date:  2006-04-25       Impact factor: 3.154

3.  Risk of adverse birth outcome and miscarriage in pregnant users of non-steroidal anti-inflammatory drugs: population based observational study and case-control study.

Authors:  G L Nielsen; H T Sørensen; H Larsen; L Pedersen
Journal:  BMJ       Date:  2001-02-03

4.  Efficacy and safety of indomethacin versus ritodrine in the management of preterm labor: a randomized study.

Authors:  W J Morales; S G Smith; J L Angel; W F O'Brien; R A Knuppel
Journal:  Obstet Gynecol       Date:  1989-10       Impact factor: 7.661

5.  Safety of nonsteroidal antiinflammatory drugs in pregnant patients with rheumatic disease.

Authors:  M Ostensen; H Ostensen
Journal:  J Rheumatol       Date:  1996-06       Impact factor: 4.666

6.  Randomized comparative trial of indomethacin and ritodrine for the long-term treatment of preterm labor.

Authors:  R E Besinger; J R Niebyl; W G Keyes; T R Johnson
Journal:  Am J Obstet Gynecol       Date:  1991-04       Impact factor: 8.661

Review 7.  NSAID-induced nephrotoxicity from the fetus to the child.

Authors:  L Cuzzolin; M Dal Cerè; V Fanos
Journal:  Drug Saf       Date:  2001-01       Impact factor: 5.606

8.  Increased incidence of bronchopulmonary dysplasia after antenatal administration of indomethacin to prevent preterm labor.

Authors:  M Eronen; E Pesonen; T Kurki; K Teramo; O Ylikorkala; M Hallman
Journal:  J Pediatr       Date:  1994-05       Impact factor: 4.406

9.  Effects of aspirin consumption during pregnancy on pregnancy outcomes: meta-analysis.

Authors:  Eran Kozer; Adriana Moldovan Costei; Rada Boskovic; Irena Nulman; Shekoufeh Nikfar; Gideon Koren
Journal:  Birth Defects Res B Dev Reprod Toxicol       Date:  2003-02

10.  A randomized double-dummy comparison between indomethacin and nylidrin in threatened preterm labor.

Authors:  T Kurki; M Eronen; R Lumme; O Ylikorkala
Journal:  Obstet Gynecol       Date:  1991-12       Impact factor: 7.661
  10 in total

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