Literature DB >> 1605730

Efficacy of various oximes against GF (cyclohexyl methylphosphonofluoridate) poisoning in mice.

J G Clement1.   

Abstract

The efficacy of oxime (HI-6, toxogonin or PAM Cl) therapy against GF (cyclohexyl methylphosphonofluoridate) poisoning was assessed in mice. It was found that the combinations of atropine and either toxogonin or HI-6 were effective therapies against GF poisoning. PAM therapy was ineffective. HI-6 was the only oxime which reactivated GF inhibited acetylcholinesterase. This might explain the reason why the HI-6 treated mice appeared to recover more quickly from the incapacitating effects following GF poisoning.

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Year:  1992        PMID： 1605730     DOI： 10.1007/bf02342509

Source DB:  PubMed          Journal:  Arch Toxicol        ISSN： 0340-5761            Impact factor:   5.153


  4 in total

1.  A new and rapid colorimetric determination of acetylcholinesterase activity.

Authors:  G L ELLMAN; K D COURTNEY; V ANDRES; R M FEATHER-STONE
Journal:  Biochem Pharmacol       Date:  1961-07       Impact factor: 5.858

2.  The use of therapeutic mixtures in the treatment of cholinesterase inhibition.

Authors:  D Gall
Journal:  Fundam Appl Toxicol       Date:  1981 Mar-Apr

3.  HI-6 therapy of soman and tabun poisoning in primates and rodents.

Authors:  M G Hamilton; P M Lundy
Journal:  Arch Toxicol       Date:  1989       Impact factor: 5.153

4.  Efficacy of mono- and bis-pyridinium oximes versus soman, sarin and tabun poisoning in mice.

Authors:  J G Clement
Journal:  Fundam Appl Toxicol       Date:  1983 Nov-Dec
  4 in total
  2 in total

Review 1.  Resurrection and Reactivation of Acetylcholinesterase and Butyrylcholinesterase.

Authors:  Andrew J Franjesevic; Sydney B Sillart; Jeremy M Beck; Shubham Vyas; Christopher S Callam; Christopher M Hadad
Journal:  Chemistry       Date:  2019-02-13       Impact factor: 5.236

2.  Toxicity of the combined nerve agents GB/GF in mice: efficacy of atropine and various oximes as antidotes.

Authors:  J G Clement
Journal:  Arch Toxicol       Date:  1994       Impact factor: 5.153
  2 in total

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