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Literature DB >> 6662294

Efficacy of mono- and bis-pyridinium oximes versus soman, sarin and tabun poisoning in mice.

Abstract

Various oximes (PAM, toxogonin, TMB-4, HS-6, HI-6, HGG-12, HGG-42) combined with atropine were compared as antidotes of soman, sarin and tabun poisoning in non-fasted CD-1 male mice. TMB-4 was the most toxic oxime with an i.p. LD50 value of 80 mg/kg and HI-6 was the least toxic oxime with an i.p. LD50 of 588 mg/kg. Upon comparing ED50 values, HGG-42 was the most effective oxime versus soman and tabun poisoning whereas, HI-6 was the most effective oxime versus sarin poisoning. Further research needs to be done to explain the distinct differences in efficacy of the oximes versus poisoning by soman, sarin or tabun.

Entities: Chemical Disease Gene Species

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Year: 1983 PMID： 6662294 DOI： 10.1016/s0272-0590(83)80100-6

Source DB: PubMed Journal: Fundam Appl Toxicol ISSN： 0272-0590

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Cited

14 in total

1. The acetylcholinesterase reactivator HI-6 (1-[[[4-(aminocarbonyl)pyridinio]methoxyl]methyl]- 2-[(hydroxyimino)methyl]-pyridinium dichloride): a comparative study of HI-6 samples from various sources.

Authors: J G Clement; P A Lockwood; H G Thompson
Journal: Arch Toxicol Date: 1988 Impact factor: 5.153

2. In vitro oxime-induced reactivation of various molecular forms of soman-inhibited acetylcholinesterase in striated muscle from rat, monkey and human.

Authors: J G Clement; N Erhardt
Journal: Arch Toxicol Date: 1994 Impact factor: 5.153

3. HI-6 therapy of soman and tabun poisoning in primates and rodents.

Authors: M G Hamilton; P M Lundy
Journal: Arch Toxicol Date: 1989 Impact factor: 5.153

4. Survivors of soman poisoning: recovery of the soman LD50 to control value in the presence of extensive acetylcholinesterase inhibition.

Authors: J G Clement
Journal: Arch Toxicol Date: 1989 Impact factor: 5.153

5. Efficacy of a combination of acetylcholinesterase reactivators, HI-6 and obidoxime, against tabun and soman poisoning of mice.

Authors: J G Clement; J D Shiloff; C Gennings
Journal: Arch Toxicol Date: 1987 Impact factor: 5.153

6. Pharmacokinetics of the oximes HI 6 and HLö 7 in dogs after i.m. injection with newly developed dry/wet autoinjectors.

Authors: U Spöhrer; H Thiermann; R Klimmek; P Eyer
Journal: Arch Toxicol Date: 1994 Impact factor: 5.153

Efficacy of mono- and bis-pyridinium oximes versus soman, sarin and tabun poisoning in mice.

1. The acetylcholinesterase reactivator HI-6 (1-[[[4-(aminocarbonyl)pyridinio]methoxyl]methyl]- 2-[(hydroxyimino)methyl]-pyridinium dichloride): a comparative study of HI-6 samples from various sources.

2. In vitro oxime-induced reactivation of various molecular forms of soman-inhibited acetylcholinesterase in striated muscle from rat, monkey and human.

3. HI-6 therapy of soman and tabun poisoning in primates and rodents.

4. Survivors of soman poisoning: recovery of the soman LD50 to control value in the presence of extensive acetylcholinesterase inhibition.

5. Efficacy of a combination of acetylcholinesterase reactivators, HI-6 and obidoxime, against tabun and soman poisoning of mice.

6. Pharmacokinetics of the oximes HI 6 and HLö 7 in dogs after i.m. injection with newly developed dry/wet autoinjectors.

7. Operational evaluation of three commercial configurations of atropine/HI-6 wet/dry autoinjectors.

8. Toxicity of the combined nerve agents GB/GF in mice: efficacy of atropine and various oximes as antidotes.

9. HLö 7 dimethanesulfonate, a potent bispyridinium-dioxime against anticholinesterases.

10. Efficacy of HLö-7 and pyrimidoxime as antidotes of nerve agent poisoning in mice.