Literature DB >> 1605620

Inhibitory effects of polyethers on human immunodeficiency virus replication.

M Nakamura1, S Kunimoto, Y Takahashi, H Naganawa, M Sakaue, S Inoue, T Ohno, T Takeuchi.   

Abstract

We examined the inhibitory activities of 10 polyether antibiotics on human immunodeficiency virus (HIV) type 1. These compounds caused concentration-dependent inhibition of HIV replication in primary infected cultures of human T-lymphoblastoid H9 cells. The ratio of 50% effective concentrations for cellular cytotoxicity (MTT assay) to antiviral activity (reverse transcriptase assay) was over 5. Anti-HIV activity was also observed in cultures of monocytic lineage U937 cells chronically infected with HIV.

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Year:  1992        PMID： 1605620      PMCID： PMC188467          DOI： 10.1128/AAC.36.2.492

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  15 in total

1.  Biosynthesis and processing of human immunodeficiency virus type 1 envelope glycoproteins: effects of monensin on glycosylation and transport.

Authors:  R L Dewar; M B Vasudevachari; V Natarajan; N P Salzman
Journal:  J Virol       Date:  1989-06       Impact factor: 5.103

2.  The role of mononuclear phagocytes in HTLV-III/LAV infection.

Authors:  S Gartner; P Markovits; D M Markovitz; M H Kaplan; R C Gallo; M Popovic
Journal:  Science       Date:  1986-07-11       Impact factor: 47.728

3.  Infection of monocyte/macrophages by human T lymphotropic virus type III.

Authors:  D D Ho; T R Rota; M S Hirsch
Journal:  J Clin Invest       Date:  1986-05       Impact factor: 14.808

4.  Inhibitory effect of dextran sulfate and heparin on the replication of human immunodeficiency virus (HIV) in vitro.

Authors:  M Ito; M Baba; A Sato; R Pauwels; E De Clercq; S Shigeta
Journal:  Antiviral Res       Date:  1987-07       Impact factor: 5.970

Review 5.  The macrophage in the persistence and pathogenesis of HIV infection.

Authors:  H E Gendelman; J M Orenstein; L M Baca; B Weiser; H Burger; D C Kalter; M S Meltzer
Journal:  AIDS       Date:  1989-08       Impact factor: 4.177

6.  Monensin, a new biologically active compound. VI. Anticoccidial activity.

Authors:  R F Shumard; M E Callender
Journal:  Antimicrob Agents Chemother (Bethesda)       Date:  1967

7.  Characterization of the AIDS-associated retrovirus reverse transcriptase and optimal conditions for its detection in virions.

Authors:  A D Hoffman; B Banapour; J A Levy
Journal:  Virology       Date:  1985-12       Impact factor: 3.616

8.  The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus.

Authors:  A G Dalgleish; P C Beverley; P R Clapham; D H Crawford; M F Greaves; R A Weiss
Journal:  Nature       Date:  1984 Dec 20-1985 Jan 2       Impact factor: 49.962

9.  Dextran sulfate suppression of viruses in the HIV family: inhibition of virion binding to CD4+ cells.

Authors:  H Mitsuya; D J Looney; S Kuno; R Ueno; F Wong-Staal; S Broder
Journal:  Science       Date:  1988-04-29       Impact factor: 47.728

10.  A study of some variables in a tetrazolium dye (MTT) based assay for cell growth and chemosensitivity.

Authors:  P R Twentyman; M Luscombe
Journal:  Br J Cancer       Date:  1987-09       Impact factor: 7.640
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  9 in total

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2.  Polyether ionophores: broad-spectrum and promising biologically active molecules for the control of drug-resistant bacteria and parasites.

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Journal:  Expert Opin Drug Discov       Date:  2009-02       Impact factor: 6.098

3.  Mechanism of thioesterase-catalyzed chain release in the biosynthesis of the polyether antibiotic nanchangmycin.

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Journal:  Chem Biol       Date:  2008-05

4.  A high throughput Cre-lox activated viral membrane fusion assay identifies pharmacological inhibitors of HIV entry.

Authors:  Anthony M Esposito; Pamela Cheung; Talia H Swartz; Hongru Li; Tshidi Tsibane; Natasha D Durham; Christopher F Basler; Dan P Felsenfeld; Benjamin K Chen
Journal:  Virology       Date:  2016-01-21       Impact factor: 3.616

5.  Intermediates in monensin biosynthesis: A late step in biosynthesis of the polyether ionophore monensin is crucial for the integrity of cation binding.

Authors:  Wolfgang Hüttel; Jonathan B Spencer; Peter F Leadlay
Journal:  Beilstein J Org Chem       Date:  2014-02-10       Impact factor: 2.883

Review 6.  Properties and Mechanisms of Flavin-Dependent Monooxygenases and Their Applications in Natural Product Synthesis.

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Journal:  Int J Mol Sci       Date:  2022-02-27       Impact factor: 5.923

7.  Approach to nigericin derivatives and their therapeutic potential.

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8.  Ionophore Antibiotics Inhibit Type II Feline Coronavirus Proliferation In Vitro.

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9.  Discovery of Novel Cyclic Ethers with Synergistic Antiplasmodial Activity in Combination with Valinomycin.

Authors:  Daniel J Watson; Paul R Meyers; Kojo Sekyi Acquah; Godwin A Dziwornu; Christopher Bevan Barnett; Lubbe Wiesner
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  9 in total

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