| Literature DB >> 16055554 |
Osamu Takeuchi1, Jill Fisher, Heikyung Suh, Hisashi Harada, Barbara A Malynn, Stanley J Korsmeyer.
Abstract
B cell homeostasis is maintained by a balance between the continual generation of new cells and their elimination. Here we show proapoptotic BCL-2 family members BAX and BAK are essential for regulating the number of B cells at both immature and mature developmental stages. BAX and BAK are critical mediators of B cell death induced by multiple stimuli. In addition, BAX- and BAK-deficient B cells display defective cell cycle progression to B cell receptor crosslinking and lipopolysaccharide, but not to CpG-DNA. Furthermore, inducible deletion of Bax and Bak in adult mice results in the development of severe autoimmune disease.Entities:
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Year: 2005 PMID： 16055554 PMCID： PMC1183578 DOI： 10.1073/pnas.0504783102
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205