Literature DB >> 11983156

Pathways of apoptosis in lymphocyte development, homeostasis, and disease.

Jeffrey C Rathmell1, Craig B Thompson.   

Abstract

Apoptosis plays a critical role in lymphocyte development and homeostasis. Enhanced lymphocyte apoptosis can cause immunodeficiency through cell loss. Conversely, inhibition of apoptosis can lead to the development of autoimmunity or lymphoma. Two major pathways contribute to the regulation of lymphocyte cell death, death-by-neglect and death-by-instruction.

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Year:  2002        PMID： 11983156     DOI： 10.1016/s0092-8674(02)00704-3

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  119 in total

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9.  Direct measurement of cathepsin B activity in the cytosol of apoptotic cells by an activity-based probe.

Authors:  Matthew R Pratt; Matthew D Sekedat; Kyle P Chiang; Tom W Muir
Journal:  Chem Biol       Date:  2009-09-25

10.  Cytoprotective effects of IAPs revealed by a small molecule antagonist.

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