Literature DB >> 16055020

Blocking the insulin-like growth factor-I receptor as a strategy for targeting cancer.

Francesco Hofmann1, Carlos García-Echeverría.   

Abstract

Clear links between cancer and cellular signaling triggered by the insulin-like growth factor-I (IGF-I) receptor (IGF-IR) and its cognate ligands (IGF-I and IGF-II) have been reported throughout the past two decades. Experimental results suggest that the pharmaceutical targeting of this signaling pathway could be beneficial for the treatment of cancer. Here, more recent advances towards potentially clinically viable strategies to interfere with the function of IGF-IR will be discussed.

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Year:  2005        PMID： 16055020     DOI： 10.1016/S1359-6446(05)03512-9

Source DB:  PubMed          Journal:  Drug Discov Today        ISSN： 1359-6446            Impact factor:   7.851


  39 in total

Review 1.  Cell signalling: growth factors and tyrosine kinase receptors.

Authors:  Rosario Perona
Journal:  Clin Transl Oncol       Date:  2006-02       Impact factor: 3.405

2.  The anti-angiogenic peptide, loop 6, binds insulin-like growth factor-1 receptor.

Authors:  Cecilia A Fernandez; Roopali Roy; Sunyoung Lee; Jiang Yang; Dipak Panigrahy; Krystyn J Van Vliet; Marsha A Moses
Journal:  J Biol Chem       Date:  2010-10-12       Impact factor: 5.157

3.  Synthesis of aryl-heteroaryl ureas (AHUs) based on 4-aminoquinoline and their evaluation against the insulin-like growth factor receptor (IGF-1R).

Authors:  William Engen; Terrence E O'Brien; Brendan Kelly; Jacinda Do; Liezel Rillera; Lance K Stapleton; Jack F Youngren; Marc O Anderson
Journal:  Bioorg Med Chem       Date:  2010-06-25       Impact factor: 3.641

4.  Sequence-specific targeting of IGF-I and IGF-IR genes by camptothecins.

Authors:  Kahina Oussedik; Jean-Christophe François; Ludovic Halby; Catherine Senamaud-Beaufort; Géraldine Toutirais; Sabrina Dallavalle; Yves Pommier; Claudio Pisano; Paola B Arimondo
Journal:  FASEB J       Date:  2010-02-23       Impact factor: 5.191

Review 5.  Insulin receptor (IR) and insulin-like growth factor receptor 1 (IGF-1R) signaling systems: novel treatment strategies for cancer.

Authors:  Pushpendra Singh; Jimi Marin Alex; Felix Bast
Journal:  Med Oncol       Date:  2013-12-14       Impact factor: 3.064

6.  Human monoclonal antibody fragments binding to insulin-like growth factors I and II with picomolar affinity.

Authors:  Qi Zhao; Yang Feng; Zhongyu Zhu; Dimiter S Dimitrov
Journal:  Mol Cancer Ther       Date:  2011-07-12       Impact factor: 6.261

Review 7.  Role of insulin-like growth factor-1R system in colorectal carcinogenesis.

Authors:  Erin A Donovan; Shivaani Kummar
Journal:  Crit Rev Oncol Hematol       Date:  2007-10-31       Impact factor: 6.312

Review 8.  Targeted medical therapy of biliary tract cancer: recent advances and future perspectives.

Authors:  Michael Hopfner; Detlef Schuppan; Hans Scherubl
Journal:  World J Gastroenterol       Date:  2008-12-14       Impact factor: 5.742

Review 9.  Early drug development of inhibitors of the insulin-like growth factor-I receptor pathway: lessons from the first clinical trials.

Authors:  Jordi Rodon; Victoria DeSantos; Robert Jean Ferry; Razelle Kurzrock
Journal:  Mol Cancer Ther       Date:  2008-09       Impact factor: 6.261

Review 10.  Treatment of gastrointestinal neuroendocrine tumors with inhibitors of growth factor receptors and their signaling pathways: recent advances and future perspectives.

Authors:  Michael Höpfner; Detlef Schuppan; Hans Scherübl
Journal:  World J Gastroenterol       Date:  2008-04-28       Impact factor: 5.742
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