Literature DB >> 16054819

Synthesis of 4-pyrido-6-aryl-2-substituted amino pyrimidines as a new class of antimalarial agents.

Anu Agarwal1, Kumkum Srivastava, S K Puri, Prem M S Chauhan.   

Abstract

A series of 2,4,6-trisubstituted pyrimidines were synthesized and evaluated for their in vitro antimalarial activity against Plasmodium falciparum. Of the 18 compounds synthesized, 14 compounds showed MIC in the range of 0.25-2 microg/mL. These compounds are in vitro several fold more active than pyrimethamine.

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Year:  2005        PMID： 16054819     DOI： 10.1016/j.bmc.2005.06.052

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  5 in total

1.  2-Aminopyrimidine based 4-aminoquinoline anti-plasmodial agents. Synthesis, biological activity, structure-activity relationship and mode of action studies.

Authors:  Kamaljit Singh; Hardeep Kaur; Kelly Chibale; Jan Balzarini; Susan Little; Prasad V Bharatam
Journal:  Eur J Med Chem       Date:  2012-03-13       Impact factor: 6.514

2.  Synthesis of a new series of substituted pyrimidines and its evaluation for antibacterial and antinociceptive effects.

Authors:  Akhlaq Waheed; Mohammad S Alorainy; Abdullah A Alghasham; Suroor A Khan; Muhammad Raza
Journal:  Int J Health Sci (Qassim)       Date:  2008-01

3.  A facile synthesis, and antimicrobial and anticancer activities of some pyridines, thioamides, thiazole, urea, quinazoline, β-naphthyl carbamate, and pyrano[2,3-d]thiazole derivatives.

Authors:  Yasser H Zaki; Marwa S Al-Gendey; Abdou O Abdelhamid
Journal:  Chem Cent J       Date:  2018-06-20       Impact factor: 4.215

4.  DFT, ADMET and Molecular Docking Investigations for the Antimicrobial Activity of 6,6'-Diamino-1,1',3,3'-tetramethyl-5,5'-(4-chlorobenzylidene)bis[pyrimidine-2,4(1H,3H)-dione].

Authors:  Nesreen T El-Shamy; Ahmed M Alkaoud; Rageh K Hussein; Moez A Ibrahim; Abdulrahman G Alhamzani; Mortaga M Abou-Krisha
Journal:  Molecules       Date:  2022-01-18       Impact factor: 4.411

5.  Synthesis, Reactions and Evaluation of the Antimicrobial Activity of Some 4-(p-Halophenyl)-4H-naphthopyran, Pyranopyrimidine and Pyranotriazolopyrimidine Derivatives.

Authors:  Ashraf H F Abd El-Wahab
Journal:  Pharmaceuticals (Basel)       Date:  2012-07-12
  5 in total

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