Literature DB >> 16054368

4-Aminoquinoline quinolizidinyl- and quinolizidinylalkyl-derivatives with antimalarial activity.

Anna Sparatore1, Nicoletta Basilico, Silvia Parapini, Sergio Romeo, Federica Novelli, Fabio Sparatore, Donatella Taramelli.   

Abstract

A set of quinolizidinyl and quinolizidinylalkyl derivatives of 4-amino-7-chloroquinoline and of 9-amino-6-chloro-2-methoxyacridine were prepared and tested in vitro against CQ-sensitive (D-10) and CQ-resistant (W-2) strains of Plasmodium falciparum. All compounds but one exerted significant antimalarial activity. Some of the quinolizidine derivatives were from 5 to 10 times more active than chloroquine on the CQ-resistant strain. No toxicity against mammalian cells was observed.

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Year:  2005        PMID： 16054368     DOI： 10.1016/j.bmc.2005.06.047

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  7 in total

1.  Efficacy of novel acridine derivatives in the inhibition of hPrP90-231 prion protein fragment toxicity.

Authors:  Valentina Villa; Michele Tonelli; Stefano Thellung; Alessandro Corsaro; Bruno Tasso; Federica Novelli; Caterina Canu; Albiana Pino; Katia Chiovitti; Domenico Paludi; Claudio Russo; Anna Sparatore; Antonio Aceto; Vito Boido; Fabio Sparatore; Tullio Florio
Journal:  Neurotox Res       Date:  2010-04-20       Impact factor: 3.911

2.  Primary anti-proliferative activity evaluation of 1-(quinolizidin-1'-yl)methyl- and 1-(ω-tert-amino)alkyl-substituted 2-phenyl-, 2-benzyl- and 2-[(benzotriazol-1/2-yl)methyl]benzimidazoles on human cancer cell lines.

Authors:  Michele Tonelli; Bruno Tasso; Lorenzo Mina; Giuseppe Paglietti; Vito Boido; Fabio Sparatore
Journal:  Mol Divers       Date:  2013-04-13       Impact factor: 2.943

3.  Novel antimalarial aminoquinolines: heme binding and effects on normal or Plasmodium falciparum-parasitized human erythrocytes.

Authors:  Fausta Omodeo-Salè; Lucia Cortelezzi; Nicoletta Basilico; Manolo Casagrande; Anna Sparatore; Donatella Taramelli
Journal:  Antimicrob Agents Chemother       Date:  2009-08-03       Impact factor: 5.191

Review 4.  Quinoline-Based Hybrid Compounds with Antimalarial Activity.

Authors:  Xhamla Nqoro; Naki Tobeka; Blessing A Aderibigbe
Journal:  Molecules       Date:  2017-12-19       Impact factor: 4.411

Review 5.  Acridine-Based Antimalarials-From the Very First Synthetic Antimalarial to Recent Developments.

Authors:  Mélanie Fonte; Natália Tassi; Paula Gomes; Cátia Teixeira
Journal:  Molecules       Date:  2021-01-24       Impact factor: 4.411

6.  In Vivo and In Vitro Activities and ADME-Tox Profile of a Quinolizidine-Modified 4-Aminoquinoline: A Potent Anti-P. falciparum and Anti-P. vivax Blood-Stage Antimalarial.

Authors:  Nicoletta Basilico; Silvia Parapini; Anna Sparatore; Sergio Romeo; Paola Misiano; Livia Vivas; Vanessa Yardley; Simon L Croft; Annette Habluetzel; Leonardo Lucantoni; Laurent Renia; Bruce Russell; Rossarin Suwanarusk; Francois Nosten; Giulio Dondio; Chiara Bigogno; Daniela Jabes; Donatella Taramelli
Journal:  Molecules       Date:  2017-12-01       Impact factor: 4.411

7.  Facile Preparation of N-Glycosylated 10-Piperazinyl Artemisinin Derivatives and Evaluation of Their Antimalarial and Cytotoxic Activities.

Authors:  Yuet Wu; Silvia Parapini; Ian D Williams; Paola Misiano; Ho Ning Wong; Donatella Taramelli; Nicoletta Basilico; Richard K Haynes
Journal:  Molecules       Date:  2018-07-13       Impact factor: 4.411
  7 in total

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