| Literature DB >> 16054358 |
Biswajit Das1, Sonali Rudra, Ajay Yadav, Abhijit Ray, A V S Raja Rao, A S S V Srinivas, Ajay Soni, Suman Saini, Shalini Shukla, Manisha Pandya, Pragya Bhateja, Sunita Malhotra, Tarun Mathur, S K Arora, Ashok Rattan, Anita Mehta.
Abstract
Novel oxazolidinones were synthesized containing a number of substituted five-membered heterocycles attached to the 'piperazinyl-phenyl-oxazolidinone' core of eperezolid. Further, the piperazine ring of the core was replaced by other diamino-heterocycles. These modifications led to several compounds with potent activity against a spectrum of resistant and susceptible gram-positive organisms, along with the identification of ranbezolid (RBx 7644) as a clinical candidate.Entities:
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Year: 2005 PMID： 16054358 DOI： 10.1016/j.bmcl.2005.06.063
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823