| Literature DB >> 16054083 |
Abstract
The role of reactive oxygen species (ROS) in the cellular response to cellular oxygen sensing has been controversial. Three papers in this issue of Cell Metabolism (Brunelle et al., Guzy et al., 2005; Mansfield et al., 2005) used genetic tools to establish that ROS produced by mitochondria are required for the normal induction of HIF (hypoxia-inducible factor), which is a master regulator of oxygen-sensitive gene expression, by low oxygen.Entities:
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Year: 2005 PMID： 16054083 DOI： 10.1016/j.cmet.2005.05.006
Source DB: PubMed Journal: Cell Metab ISSN： 1550-4131 Impact factor: 27.287