| Literature DB >> 16054075 |
Alan D Attie1, Nabil G Seidah.
Abstract
Upregulation of the expression of the LDL receptor (LDLR) gene does not always lead to an increase in the LDLR protein. While the mRNA expression of the LDLR and the newly studied proprotein convertase PCSK9 are coordinately upregulated in absence of sterols, the latter proteinase apparently enhances the degradation of the LDLR protein.Entities:
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Year: 2005 PMID： 16054075 DOI： 10.1016/j.cmet.2005.04.006
Source DB: PubMed Journal: Cell Metab ISSN： 1550-4131 Impact factor: 27.287