Literature DB >> 16049526

Aurora kinases: shining lights on the therapeutic horizon?

Paul D Andrews1.   

Abstract

The Aurora kinases have been implicated in tumorigenesis and are important regulators of diverse cell cycle events, ranging from the entry into mitosis, centrosome function, mitotic spindle formation, chromosome biorientation and segregation, and cytokinesis. The recent identification of novel binding partners and key downstream effectors, together with new small-molecule inhibitors that display efficacy against tumours, heralds an upsurge of interest in these critical kinases. This review details new developments in the field and analyses the potential of Aurora kinases as anticancer targets.

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Year:  2005        PMID： 16049526     DOI： 10.1038/sj.onc.1208752

Source DB:  PubMed          Journal:  Oncogene        ISSN： 0950-9232            Impact factor:   9.867


  49 in total

1.  Phase I study of barasertib (AZD1152), a selective inhibitor of Aurora B kinase, in patients with advanced solid tumors.

Authors:  Gary K Schwartz; Richard D Carvajal; Rachel Midgley; Scott J Rodig; Paul K Stockman; Ozlem Ataman; David Wilson; Shampa Das; Geoffrey I Shapiro
Journal:  Invest New Drugs       Date:  2012-06-02       Impact factor: 3.850

2.  Synthesis and SAR studies of novel 6,7,8-substituted 4-substituted benzyloxyquinolin-2(1H)-one derivatives for anticancer activity.

Authors:  Yi-Fong Chen; Yi-Chien Lin; Susan L Morris-Natschke; Chen-Fang Wei; Ting-Chen Shen; Hui-Yi Lin; Mei-Hua Hsu; Li-Chen Chou; Yu Zhao; Sheng-Chu Kuo; Kuo-Hsiung Lee; Li-Jiau Huang
Journal:  Br J Pharmacol       Date:  2015-01-13       Impact factor: 8.739

3.  MK615 inhibits pancreatic cancer cell growth by dual inhibition of Aurora A and B kinases.

Authors:  Toshie Okada; Tokihiko Sawada; Tatsushi Osawa; Masakazu Adachi; Keiichi Kubota
Journal:  World J Gastroenterol       Date:  2008-03-07       Impact factor: 5.742

4.  A microtubule-independent role for centrosomes and aurora a in nuclear envelope breakdown.

Authors:  Nathan Portier; Anjon Audhya; Paul S Maddox; Rebecca A Green; Alexander Dammermann; Arshad Desai; Karen Oegema
Journal:  Dev Cell       Date:  2007-04       Impact factor: 12.270

5.  Recognizing and exploiting differences between RNAi and small-molecule inhibitors.

Authors:  William A Weiss; Stephen S Taylor; Kevan M Shokat
Journal:  Nat Chem Biol       Date:  2007-12       Impact factor: 15.040

6.  Modeling the temporal evolution of the spindle assembly checkpoint and role of Aurora B kinase.

Authors:  Hitesh B Mistry; David E MacCallum; Robert C Jackson; Mark A J Chaplain; Fordyce A Davidson
Journal:  Proc Natl Acad Sci U S A       Date:  2008-12-17       Impact factor: 11.205

7.  Structural studies of B-type Aurora kinase inhibitors using computational methods.

Authors:  Mm Neaz; M Muddassar; Fa Pasha; Seung Joo Cho
Journal:  Acta Pharmacol Sin       Date:  2010-02       Impact factor: 6.150

8.  Ubiquitin-specific cysteine protease 2a (USP2a) regulates the stability of Aurora-A.

Authors:  Yan Shi; Larry R Solomon; Ana Pereda-Lopez; Vincent L Giranda; Yan Luo; Eric F Johnson; Alexander R Shoemaker; Joel Leverson; Xuesong Liu
Journal:  J Biol Chem       Date:  2011-09-02       Impact factor: 5.157

9.  Identification of Ski as a target for Aurora A kinase.

Authors:  Jocelyn Mosquera; Ricardo Armisen; Hongling Zhao; Diego A Rojas; Edio Maldonado; Julio C Tapia; Alicia Colombo; Michael J Hayman; Katherine Marcelain
Journal:  Biochem Biophys Res Commun       Date:  2011-05-12       Impact factor: 3.575

10.  Quantitation of Aurora kinase A gene copy number in urine sediments and bladder cancer detection.

Authors:  Hong-Seok Park; Weon Seo Park; Jolanta Bondaruk; Noriyoshi Tanaka; Hiroshi Katayama; Sangkyou Lee; Philippe E Spiess; Jordan R Steinberg; Zhi Wang; Ruth L Katz; Colin Dinney; Keren J Elias; Yair Lotan; Rizwan C Naeem; Keith Baggerly; Subrata Sen; H Barton Grossman; Bogdan Czerniak
Journal:  J Natl Cancer Inst       Date:  2008-09-23       Impact factor: 13.506
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