Literature DB >> 16048976

Effect of antibiotic treatment on growth of and toxin production by Clostridium difficile in the cecal contents of mice.

Nicole J Pultz1, Curtis J Donskey.   

Abstract

In mice, subcutaneous administration of antibiotics that disrupt the anaerobic microflora (i.e., clindamycin, piperacillin-tazobactam, and ceftriaxone) facilitated in vitro growth of and toxin production by Clostridium difficile in cecal contents, whereas antibiotics that cause minimal disruption of the anaerobic microflora (i.e., levofloxacin, cefepime, and aztreonam) did not.

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Year:  2005        PMID： 16048976      PMCID： PMC1196291          DOI： 10.1128/AAC.49.8.3529-3532.2005

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  19 in total

Review 1.  The role of the intestinal tract as a reservoir and source for transmission of nosocomial pathogens.

Authors:  Curtis J Donskey
Journal:  Clin Infect Dis       Date:  2004-06-25       Impact factor: 9.079

2.  Clindamycin, cephalosporins, fluoroquinolones, and Clostridium difficile-associated diarrhea: this is an antimicrobial resistance problem.

Authors:  Dale N Gerding
Journal:  Clin Infect Dis       Date:  2004-02-11       Impact factor: 9.079

3.  Frequency of antibiotic-associated diarrhoea in 2462 antibiotic-treated hospitalized patients: a prospective study.

Authors:  J Wiström; S R Norrby; E B Myhre; S Eriksson; G Granström; L Lagergren; G Englund; C E Nord; B Svenungsson
Journal:  J Antimicrob Chemother       Date:  2001-01       Impact factor: 5.790

4.  Quinolone use as a risk factor for nosocomial Clostridium difficile-associated diarrhea.

Authors:  C Yip; M Loeb; S Salama; L Moss; J Olde
Journal:  Infect Control Hosp Epidemiol       Date:  2001-09       Impact factor: 3.254

Review 5.  Effect of antimicrobial agents on the ecological balance of human microflora.

Authors:  A Sullivan; C Edlund; C E Nord
Journal:  Lancet Infect Dis       Date:  2001-09       Impact factor: 25.071

6.  Effects of cefotaxime and desacetylcefotaxime upon Clostridium difficile proliferation and toxin production in a triple-stage chemostat model of the human gut.

Authors:  Jane Freeman; Fiona J O'Neill; Mark H Wilcox
Journal:  J Antimicrob Chemother       Date:  2003-05-29       Impact factor: 5.790

7.  Increased susceptibility to vancomycin-resistant Enterococcus intestinal colonization persists after completion of anti-anaerobic antibiotic treatment in mice.

Authors:  Usha Stiefel; Nicole J Pultz; Marion S Helfand; Curtis J Donskey
Journal:  Infect Control Hosp Epidemiol       Date:  2004-05       Impact factor: 3.254

8.  Effect of parenteral fluoroquinolone administration on persistence of vancomycin-resistant Enterococcus faecium in the mouse gastrointestinal tract.

Authors:  Curtis J Donskey; Marion S Helfand; Nicole J Pultz; Louis B Rice
Journal:  Antimicrob Agents Chemother       Date:  2004-01       Impact factor: 5.191

9.  Long-term surveillance of cefotaxime and piperacillin-tazobactam prescribing and incidence of Clostridium difficile diarrhoea.

Authors:  Mark H Wilcox; Jane Freeman; Warren Fawley; Sarah MacKinlay; Alex Brown; Katrina Donaldson; Oliver Corrado
Journal:  J Antimicrob Chemother       Date:  2004-05-26       Impact factor: 5.790

10.  Fluoroquinolone use and Clostridium difficile-associated diarrhea.

Authors:  Margaret E McCusker; Anthony D Harris; Eli Perencevich; Mary-Claire Roghmann
Journal:  Emerg Infect Dis       Date:  2003-06       Impact factor: 6.883
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  35 in total

1.  Meta-analysis of antibiotics and the risk of community-associated Clostridium difficile infection.

Authors:  Kevin A Brown; Nagham Khanafer; Nick Daneman; David N Fisman
Journal:  Antimicrob Agents Chemother       Date:  2013-03-11       Impact factor: 5.191

Review 2.  Vaccines against Clostridium difficile.

Authors:  Rosanna Leuzzi; Roberto Adamo; Maria Scarselli
Journal:  Hum Vaccin Immunother       Date:  2014-03-17       Impact factor: 3.452

3.  Effect of ceftobiprole treatment on growth of and toxin production by Clostridium difficile in cecal contents of mice.

Authors:  Michelle M Nerandzic; Curtis J Donskey
Journal:  Antimicrob Agents Chemother       Date:  2011-02-22       Impact factor: 5.191

4.  Gastrointestinal colonization with a cephalosporinase-producing bacteroides species preserves colonization resistance against vancomycin-resistant enterococcus and Clostridium difficile in cephalosporin-treated mice.

Authors:  Usha Stiefel; Michelle M Nerandzic; Michael J Pultz; Curtis J Donskey
Journal:  Antimicrob Agents Chemother       Date:  2014-05-27       Impact factor: 5.191

5.  Variation in Risk of Hospital-Onset Clostridium difficile Infection Across β-Lactam Antibiotics in Children With New-Onset Acute Lymphoblastic Leukemia.

Authors:  Brian T Fisher; Julia Shaklee Sammons; Yimei Li; Peter de Blank; Alix E Seif; Yuan-Shung Huang; Marko Kavcic; Sarah Klieger; Tracey Harris; Kari Torp; Douglas Rheam; Ami Shah; Richard Aplenc
Journal:  J Pediatric Infect Dis Soc       Date:  2014-02-16       Impact factor: 3.164

6.  The interplay between microbiome dynamics and pathogen dynamics in a murine model of Clostridium difficile Infection.

Authors:  Angela E Reeves; Casey M Theriot; Ingrid L Bergin; Gary B Huffnagle; Patrick D Schloss; Vincent B Young
Journal:  Gut Microbes       Date:  2011-05-01

7.  Effects of ciprofloxacin on the expression and production of exotoxins by Clostridium difficile.

Authors:  Michael John Aldape; Aaron Eugene Packham; Drew William Nute; Amy Evelyn Bryant; Dennis Leroy Stevens
Journal:  J Med Microbiol       Date:  2013-02-21       Impact factor: 2.472

Review 8.  Cefepime: a reappraisal in an era of increasing antimicrobial resistance.

Authors:  Andrea Endimiani; Federico Perez; Robert A Bonomo
Journal:  Expert Rev Anti Infect Ther       Date:  2008-12       Impact factor: 5.091

9.  Effect of fluoroquinolone treatment on growth of and toxin production by epidemic and nonepidemic clostridium difficile strains in the cecal contents of mice.

Authors:  Daniel A Adams; Michelle M Riggs; Curtis J Donskey
Journal:  Antimicrob Agents Chemother       Date:  2007-06-11       Impact factor: 5.191

10.  Metabolism of bile salts in mice influences spore germination in Clostridium difficile.

Authors:  Jennifer L Giel; Joseph A Sorg; Abraham L Sonenshein; Jun Zhu
Journal:  PLoS One       Date:  2010-01-15       Impact factor: 3.240
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