Literature DB >> 16048321

A new RNA synthetic method with a 2'-O-(2-cyanoethoxymethyl) protecting group.

Tadaaki Ohgi1, Yutaka Masutomi, Kouichi Ishiyama, Hidetoshi Kitagawa, Yoshinobu Shiba, Junichi Yano.   

Abstract

A novel method for the synthesis of RNA oligomers with 2-cyanoethoxymethyl (CEM) as the 2'-hydroxyl protecting group has been developed. The new method allows the synthesis of oligoribonucleotides with an efficiency and final purity comparable to that obtained in DNA synthesis. [structure: see text]

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Year:  2005        PMID： 16048321     DOI： 10.1021/ol051151f

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  10 in total

1.  Combined Approaches to Site-Specific Modification of RNA.

Authors:  Christine S Chow; Santosh K Mahto; Tek N Lamichhane
Journal:  ACS Chem Biol       Date:  2008-01-05       Impact factor: 5.100

Review 2.  Isotope labeling for studying RNA by solid-state NMR spectroscopy.

Authors:  Alexander Marchanka; Christoph Kreutz; Teresa Carlomagno
Journal:  J Biomol NMR       Date:  2018-04-12       Impact factor: 2.835

3.  Synthesis and biological activity of artificial mRNA prepared with novel phosphorylating reagents.

Authors:  Seigo Nagata; Tomohiro Hamasaki; Koichi Uetake; Hirofumi Masuda; Kazuchika Takagaki; Natsuhisa Oka; Takeshi Wada; Tadaaki Ohgi; Junichi Yano
Journal:  Nucleic Acids Res       Date:  2010-07-26       Impact factor: 16.971

4.  Synthetic Pre-miRNA-Based shRNA as Potent RNAi Triggers.

Authors:  Kazuya Terasawa; Kazuharu Shimizu; Gozoh Tsujimoto
Journal:  J Nucleic Acids       Date:  2011-07-12

Review 5.  Solid-Phase Chemical Synthesis of Stable Isotope-Labeled RNA to Aid Structure and Dynamics Studies by NMR Spectroscopy.

Authors:  Owen Becette; Lukasz T Olenginski; Theodore K Dayie
Journal:  Molecules       Date:  2019-09-25       Impact factor: 4.411

6.  An efficient synthesis of RNA containing GS-441524: the nucleoside precursor of remdesivir.

Authors:  Ramkumar Moorthy; Samantha A Kennelly; Deborah J Rodriguez; Daniel A Harki
Journal:  RSC Adv       Date:  2021-09-22       Impact factor: 3.361

7.  Chemical synthesis of a very long oligoribonucleotide with 2-cyanoethoxymethyl (CEM) as the 2'-O-protecting group: structural identification and biological activity of a synthetic 110mer precursor-microRNA candidate.

Authors:  Yoshinobu Shiba; Hirofumi Masuda; Naoki Watanabe; Takeshi Ego; Kazuchika Takagaki; Kouichi Ishiyama; Tadaaki Ohgi; Junichi Yano
Journal:  Nucleic Acids Res       Date:  2007-04-25       Impact factor: 16.971

8.  Detection of siRNA administered to cells and animals by using a fluorescence intensity distribution analysis polarization system.

Authors:  Takashi Abe; Kazuhito Goda; Kazunobu Futami; Yasuhiro Furuichi
Journal:  Nucleic Acids Res       Date:  2009-03-12       Impact factor: 16.971

Review 9.  Chemical Modifications of Nucleic Acid Aptamers for Therapeutic Purposes.

Authors:  Shuaijian Ni; Houzong Yao; Lili Wang; Jun Lu; Feng Jiang; Aiping Lu; Ge Zhang
Journal:  Int J Mol Sci       Date:  2017-08-02       Impact factor: 5.923

10.  Postsynthetic On-Column 2' Functionalization of RNA by Convenient Versatile Method.

Authors:  Olga A Krasheninina; Veniamin S Fishman; Alexander A Lomzov; Alexey V Ustinov; Alya G Venyaminova
Journal:  Int J Mol Sci       Date:  2020-07-20       Impact factor: 5.923
  10 in total

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