OBJECTIVE: To objectively measure individual recreational drug groups in maternal hair samples timed for the period of conception and different stages of pregnancy in expectant mothers with a diagnosis of fetal gastroschisis. DESIGN: Prospective observational study. SETTING: Tertiary level Fetal Medicine Unit in a University teaching hospital. POPULATION: Pregnant women with a diagnosis of fetal gastroschisis (n= 22) and a control group of women (n= 25) with a normal fetus. METHODS: Hair samples were cut from the vertex of the head of expectant mothers with a diagnosis of fetal gastroschisis and a matched control group in whom the fetus was normal. The samples were analysed by enzyme-linked immunosorbent assay (ELISA) for individual drug groups. Confirmatory tests using gas chromatography with mass spectrometry (GCMS) were used. MAIN OUTCOME MEASURES: Presence of recreational drug compounds in hair samples. RESULTS: In the group with fetal gastroschisis there were four proven positive cases for recreational drug abuse (18%) and there were none in the control group. CONCLUSIONS: The incidence of recreational drug use in the peri-conceptional period and the first trimester by expectant mothers with a diagnosis of fetal gastroschisis is 18%. This association may be linked to the recent increase in the incidence of gastroschisis among younger mothers.
OBJECTIVE: To objectively measure individual recreational drug groups in maternal hair samples timed for the period of conception and different stages of pregnancy in expectant mothers with a diagnosis of fetal gastroschisis. DESIGN: Prospective observational study. SETTING: Tertiary level Fetal Medicine Unit in a University teaching hospital. POPULATION: Pregnant women with a diagnosis of fetal gastroschisis (n= 22) and a control group of women (n= 25) with a normal fetus. METHODS: Hair samples were cut from the vertex of the head of expectant mothers with a diagnosis of fetal gastroschisis and a matched control group in whom the fetus was normal. The samples were analysed by enzyme-linked immunosorbent assay (ELISA) for individual drug groups. Confirmatory tests using gas chromatography with mass spectrometry (GCMS) were used. MAIN OUTCOME MEASURES: Presence of recreational drug compounds in hair samples. RESULTS: In the group with fetal gastroschisis there were four proven positive cases for recreational drug abuse (18%) and there were none in the control group. CONCLUSIONS: The incidence of recreational drug use in the peri-conceptional period and the first trimester by expectant mothers with a diagnosis of fetal gastroschisis is 18%. This association may be linked to the recent increase in the incidence of gastroschisis among younger mothers.
Authors: Martha M Werler; Samantha E Parker; Klaus Hedman; Mika Gissler; Annukka Ritvanen; Heljä-Marja Surcel Journal: Am J Epidemiol Date: 2016-11-17 Impact factor: 4.897
Authors: Anna L David; Andrew Holloway; Louise Thomasson; Argyro Syngelaki; Kypros Nicolaides; Roshni R Patel; Brian Sommerlad; Amie Wilson; William Martin; Lyn S Chitty Journal: PLoS One Date: 2014-10-31 Impact factor: 3.240
Authors: Stephen R Palmer; Annette Evans; Hannah Broughton; Simon Huddart; Mark Drayton; Judith Rankin; Elizabeth S Draper; Alan Cameron; Shantini Paranjothy Journal: PLoS One Date: 2013-11-08 Impact factor: 3.240