Literature DB >> 16041741

Morphing into cancer: the role of developmental signaling pathways in brain tumor formation.

Marie P Fogarty1, Jessica D Kessler, Robert J Wechsler-Reya.   

Abstract

Morphogens play a critical role in most aspects of development, including expansion and patterning of the central nervous system. Activating germline mutations in components of the Hedgehog and Wnt pathways have provided evidence for the important roles morphogens play in the genesis of brain tumors such as cerebellar medulloblastoma. In addition, aberrant expression of transforming growth factor-beta (TGF-beta) superfamily members has been demonstrated to contribute to progression of malignant gliomas. This review summarizes our current knowledge about the roles of morphogens in central nervous system tumorigenesis. (c) 2005 Wiley Periodicals, Inc.

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Year:  2005        PMID： 16041741     DOI： 10.1002/neu.20166

Source DB:  PubMed          Journal:  J Neurobiol        ISSN： 0022-3034


  35 in total

Review 1.  Medulloblastoma: therapy and biologic considerations.

Authors:  Timothy R Gershon; Orren J Becher
Journal:  Curr Neurol Neurosci Rep       Date:  2006-05       Impact factor: 5.081

2.  The aryl hydrocarbon receptor contributes to the proliferation of human medulloblastoma cells.

Authors:  Daniel P Dever; Lisa A Opanashuk
Journal:  Mol Pharmacol       Date:  2012-02-06       Impact factor: 4.436

Review 3.  SHH pathway and cerebellar development.

Authors:  Catherine Vaillant; Denis Monard
Journal:  Cerebellum       Date:  2009-02-18       Impact factor: 3.847

Review 4.  Epigenetic principles and mechanisms underlying nervous system functions in health and disease.

Authors:  Mark F Mehler
Journal:  Prog Neurobiol       Date:  2008-10-17       Impact factor: 11.685

5.  N-myc alters the fate of preneoplastic cells in a mouse model of medulloblastoma.

Authors:  Jessica D Kessler; Hiroshi Hasegawa; Sonja N Brun; Brian A Emmenegger; Zeng-Jie Yang; John W Dutton; Fan Wang; Robert J Wechsler-Reya
Journal:  Genes Dev       Date:  2009-01-15       Impact factor: 11.361

Review 6.  Stem cells and the origin and propagation of brain tumors.

Authors:  Brian A Emmenegger; Robert J Wechsler-Reya
Journal:  J Child Neurol       Date:  2008-10       Impact factor: 1.987

7.  Wnt/beta-catenin/Tcf signaling pathway activation in malignant progression of rat gliomas induced by transplacental N-ethyl-N-nitrosourea exposure.

Authors:  Gangadhara Reddy Sareddy; Sundaram Challa; Manas Panigrahi; Phanithi Prakash Babu
Journal:  Neurochem Res       Date:  2009-01-16       Impact factor: 3.996

8.  Genetic and protein changes of E-cadherin in meningiomas.

Authors:  Nives Pećina-Slaus; Tamara Nikuseva Martić; Adam Jakov Deak; Martina Zeljko; Reno Hrasćan; Davor Tomas; Vesna Musani
Journal:  J Cancer Res Clin Oncol       Date:  2009-11-12       Impact factor: 4.553

9.  Frequent amplification of a chr19q13.41 microRNA polycistron in aggressive primitive neuroectodermal brain tumors.

Authors:  Meihua Li; Kyle F Lee; Yuntao Lu; Ian Clarke; David Shih; Charles Eberhart; V Peter Collins; Tim Van Meter; Daniel Picard; Limei Zhou; Paul C Boutros; Piergiorgio Modena; Muh-Lii Liang; Steve W Scherer; Eric Bouffet; James T Rutka; Scott L Pomeroy; Ching C Lau; Michael D Taylor; Amar Gajjar; Peter B Dirks; Cynthia E Hawkins; Annie Huang
Journal:  Cancer Cell       Date:  2009-12-08       Impact factor: 31.743

10.  Hepatocyte growth factor and sonic Hedgehog expression in cerebellar neural progenitor cells costimulate medulloblastoma initiation and growth.

Authors:  Mandy J Binning; Toba Niazi; Carolyn A Pedone; Bachchu Lal; Charles G Eberhart; K Jin Kim; John Laterra; Daniel W Fults
Journal:  Cancer Res       Date:  2008-10-01       Impact factor: 12.701
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