Literature DB >> 16041069

Structure of the uracil-DNA N-glycosylase (UNG) from Deinococcus radiodurans.

Ingar Leiros1, Elin Moe, Arne O Smalås, Sean McSweeney.   

Abstract

Uracil-DNA glycosylases are DNA-repair enzymes that catalyse the removal of promutagenic uracil from single- and double-stranded DNA, thereby initiating the base-excision repair (BER) pathway. Uracil in DNA can occur by mis-incorporation of dUMP in place of dTMP during DNA synthesis or by deamination of cytosine, resulting in U-A or U-G mispairs. The radiation-resistant bacterium Deinococcus radiodurans has an elevated number of uracil-DNA glycosylases compared with most other organisms. The crystal structure of dr0689 (uracil-DNA N-glycosylase), which has been shown to be the major contributor to the removal of mis-incorporated uracil bases in crude cell extracts of D. radiodurans, is reported.

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Year:  2005        PMID： 16041069     DOI： 10.1107/S090744490501382X

Source DB:  PubMed          Journal:  Acta Crystallogr D Biol Crystallogr        ISSN： 0907-4449


  10 in total

1.  Structure of uracil-DNA glycosylase from Mycobacterium tuberculosis: insights into interactions with ligands.

Authors:  Prem Singh Kaushal; Ramappa K Talawar; Umesh Varshney; M Vijayan
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2010-07-27

2.  Overexpression, purification, crystallization and preliminary X-ray analysis of uracil N-glycosylase from Mycobacterium tuberculosis in complex with a proteinaceous inhibitor.

Authors:  Prem Singh; Ramappa K Talawar; P D V Krishna; Umesh Varshney; M Vijayan
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2006-11-30

3.  Structure of uracil-DNA N-glycosylase (UNG) from Vibrio cholerae: mapping temperature adaptation through structural and mutational analysis.

Authors:  Inger Lin Uttakleiv Raeder; Elin Moe; Nils Peder Willassen; Arne O Smalås; Ingar Leiros
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2010-01-26

4.  Background Mutational Features of the Radiation-Resistant Bacterium Deinococcus radiodurans.

Authors:  Hongan Long; Sibel Kucukyildirim; Way Sung; Emily Williams; Heewook Lee; Matthew Ackerman; Thomas G Doak; Haixu Tang; Michael Lynch
Journal:  Mol Biol Evol       Date:  2015-05-14       Impact factor: 16.240

Review 5.  Uracil-DNA glycosylase: Structural, thermodynamic and kinetic aspects of lesion search and recognition.

Authors:  Dmitry O Zharkov; Grigory V Mechetin; Georgy A Nevinsky
Journal:  Mutat Res       Date:  2009-11-10       Impact factor: 2.433

6.  High-resolution structure of the antibiotic resistance protein NimA from Deinococcus radiodurans.

Authors:  Hanna Kirsti S Leiros; Consiglia Tedesco; Seán M McSweeney
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2008-05-16

7.  Purification, crystallization and preliminary X-ray analysis of uracil-DNA glycosylase from Sulfolobus tokodaii strain 7.

Authors:  Akito Kawai; Shigesada Higuchi; Masaru Tsunoda; Kazuo T Nakamura; Shuichi Miyamoto
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2012-08-31

8.  Structure of the uracil complex of Vaccinia virus uracil DNA glycosylase.

Authors:  N Schormann; S Banerjee; R Ricciardi; D Chattopadhyay
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2013-11-28

Review 9.  A Decade of Biochemical and Structural Studies of the DNA Repair Machinery of Deinococcus radiodurans: Major Findings, Functional and Mechanistic Insight and Challenges.

Authors:  Joanna Timmins; Elin Moe
Journal:  Comput Struct Biotechnol J       Date:  2016-04-07       Impact factor: 7.271

10.  Structural and biophysical analysis of interactions between cod and human uracil-DNA N-glycosylase (UNG) and UNG inhibitor (Ugi).

Authors:  Netsanet Gizaw Assefa; Laila Niiranen; Kenneth A Johnson; Hanna-Kirsti Schrøder Leiros; Arne Oskar Smalås; Nils Peder Willassen; Elin Moe
Journal:  Acta Crystallogr D Biol Crystallogr       Date:  2014-07-25
  10 in total

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