| Literature DB >> 16040381 |
A Diab1, A D Cohen, O Alpdogan, M-A Perales.
Abstract
IL-15 is a pleiotropic cytokine that plays an important role in both the innate and adaptive immune system. IL-15 promotes the activation of neutrophils and macrophages, and is critical to DC function. In addition, IL-15 is essential to the development, homeostasis, function and survival of natural killer (NK) cells, NK T (NKT) cells and CD8+ T cells. Based on these properties, IL-15 has been proposed as a useful cytokine for immunotherapy. It is currently being investigated in settings of immune deficiency, for the in vitro expansion of T and NK cells, as well as an adjuvant for vaccines. In this paper, we will review the targeting of IL-15 for immunotherapy, with a particular emphasis on its effects on CD8+ T cells.Entities:
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Year: 2005 PMID： 16040381 DOI： 10.1080/14653240510018037
Source DB: PubMed Journal: Cytotherapy ISSN： 1465-3249 Impact factor: 5.414