Literature DB >> 16039521

Iteratively acting glycosyltransferases involved in the hexasaccharide biosynthesis of landomycin A.

Andriy Luzhetskyy1, Marta Fedoryshyn, Clemens Dürr, Takaaki Taguchi, Volodymyr Novikov, Andreas Bechthold.   

Abstract

Detailed studies on the biosynthesis of the hexasaccharide side chain of landomycin A, produced by S. cyanogenus S136, revealed the function of each glycosyltransferase gene of the biosynthetic gene cluster. Analyses of generated mutants as well as feeding experiments allowed us to determine that LanGT2 and LanGT3 catalyze the attachment of one sugar, whereas LanGT1 and LanGT4 attach two sugars during landomycin A biosynthesis. The generation of a lanZ2 deletion mutant provided evidence that LanZ2 is controlling the elongation of the saccharide side chain.

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Year:  2005        PMID： 16039521     DOI： 10.1016/j.chembiol.2005.05.008

Source DB:  PubMed          Journal:  Chem Biol        ISSN： 1074-5521


  17 in total

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10.  Two Cooperative Glycosyltransferases Are Responsible for the Sugar Diversity of Saquayamycins Isolated from Streptomyces sp. KY 40-1.

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