Literature DB >> 16039125

Design, synthesis, and evaluation of novelly substituted benzimidazole compounds as angiotensin II receptor antagonists.

Alka Bali1, Yogita Bansal, M Sugumaran, Jatinder Singh Saggu, P Balakumar, Gurpreet Kaur, Gulshan Bansal, Ajay Sharma, Manjeet Singh.   

Abstract

5-Nitrobenzimidazole derivatives with varying substituents at 2-position have been designed, synthesized, and evaluated for angiotensin II antagonistic activity. A drug-receptor interaction model has been proposed.

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Year:  2005        PMID： 16039125     DOI： 10.1016/j.bmcl.2005.05.054

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  4 in total

1.  Synthesis of benzimidazoles containing pyrazole group and quantum chemistry calculation of their spectroscopic properties and electronic structure.

Authors:  Tie-gang Ren; Hong-bin Cheng; Jing-lai Zhang; Wei-jie Li; Jia Guo; Li-rong Yang
Journal:  J Fluoresc       Date:  2011-08-09       Impact factor: 2.217

2.  Direct alkylation of heteroaryls using potassium alkyl- and alkoxymethyltrifluoroborates.

Authors:  Gary A Molander; Virginie Colombel; Valerie A Braz
Journal:  Org Lett       Date:  2011-03-10       Impact factor: 6.005

3.  Palladium-catalyzed regioselective synthesis of 2(2'-biphenyl)benzimidazoles through C-H activation.

Authors:  Li-Hsun Chen; Tz-Yi Wu; Vijaykumar Paike; Chung-Ming Sun
Journal:  Mol Divers       Date:  2013-07-19       Impact factor: 2.943

4.  Design, synthesis, and evaluation of 5-sulfamoyl benzimidazole derivatives as novel angiotensin II receptor antagonists.

Authors:  Navneet Kaur; Amardeep Kaur; Yogita Bansal; Dhvanit I Shah; Gulshan Bansal; Manjeet Singh
Journal:  Bioorg Med Chem       Date:  2008-10-29       Impact factor: 3.641
  4 in total

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