| Literature DB >> 16038545 |
Maurizio Bruno1, Sergio Rosselli, Antonella Maggio, Rosa Angela Raccuglia, Kenneth F Bastow, Kuo-Hsiung Lee.
Abstract
Several natural guaianolides and synthetic derivatives of repin (1) were tested and found to be active against tumor cell replication. Repin (1) and both mono- and di-halohydrin analogues (2, 7-9, 11, 12) showed significant antitumor potency. A more effective compound (17) was obtained by esterificating repin with the paclitaxel side chain.Entities:
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Year: 2005 PMID： 16038545 DOI： 10.1021/np0500575
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050