Literature DB >> 16034172

Structural biology of glycoprotein hormones and their receptors.

Qing R Fan1, Wayne A Hendrickson.   

Abstract

Glycoprotein hormones regulate reproduction in vertebrates and exert their actions through specific G protein-coupled receptors on target cell surfaces. Structural information is now available for human chorionic gonadotropin (CG), follicle-stimulating hormone (FSH), and FSH bound to the extracellular binding domain of its receptor (FSHR(HB)). The recently determined structure of a human FSH-FSHR(HB) complex provides an explanation for the specificity of glycoprotein hormones binding to their receptors, and it suggests hypotheses concerning the mechanism of transmembrane signal transduction.

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Year:  2005        PMID： 16034172     DOI： 10.1385/endo:26:3:179

Source DB:  PubMed          Journal:  Endocrine        ISSN： 1355-008X            Impact factor:   3.633


  62 in total

Review 1.  Molecular, structural, and cellular biology of follitropin and follitropin receptor.

Authors:  James A Dias; Brian D Cohen; Barbara Lindau-Shepard; Cheryl A Nechamen; Andrew J Peterson; Anja Schmidt
Journal:  Vitam Horm       Date:  2002       Impact factor: 3.421

Review 2.  Self-association and raft localization of functional luteinizing hormone receptors.

Authors:  Deborah A Roess; Steven M L Smith
Journal:  Biol Reprod       Date:  2003-07-30       Impact factor: 4.285

3.  The human follitropin alpha-subunit C terminus collaborates with a beta-subunit cystine noose and an alpha-subunit loop to assemble a receptor-binding domain competent for signal transduction.

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Journal:  Biochemistry       Date:  1998-02-17       Impact factor: 3.162

4.  Determination of residues important in hormone binding to the extracellular domain of the luteinizing hormone/chorionic gonadotropin receptor by site-directed mutagenesis and modeling.

Authors:  N Bhowmick; J Huang; D Puett; N W Isaacs; A J Lapthorn
Journal:  Mol Endocrinol       Date:  1996-09

5.  Partially deglycosylated human choriogonadotropin, stabilized by intersubunit disulfide bonds, shows full bioactivity.

Authors:  J C Heikoop; P van den Boogaart; R de Leeuw; U M Rose; J W Mulders; P D Grootenhuis
Journal:  Eur J Biochem       Date:  1998-04-01

6.  Biosynthesis of a biologically active single peptide chain containing the human common alpha and chorionic gonadotropin beta subunits in tandem.

Authors:  T Sugahara; M R Pixley; S Minami; E Perlas; D Ben-Menahem; A J Hsueh; I Boime
Journal:  Proc Natl Acad Sci U S A       Date:  1995-03-14       Impact factor: 11.205

Review 7.  Role of glycosylation in function of follicle-stimulating hormone.

Authors:  A Ulloa-Aguirre; C Timossi; P Damián-Matsumura; J A Dias
Journal:  Endocrine       Date:  1999-12       Impact factor: 3.633

8.  Conversion of human choriogonadotropin into a follitropin by protein engineering.

Authors:  R K Campbell; D M Dean-Emig; W R Moyle
Journal:  Proc Natl Acad Sci U S A       Date:  1991-02-01       Impact factor: 11.205

9.  Co-evolution of ligand-receptor pairs.

Authors:  W R Moyle; R K Campbell; R V Myers; M P Bernard; Y Han; X Wang
Journal:  Nature       Date:  1994-03-17       Impact factor: 49.962

10.  Amino-terminal leucine-rich repeats in gonadotropin receptors determine hormone selectivity.

Authors:  T Braun; P R Schofield; R Sprengel
Journal:  EMBO J       Date:  1991-07       Impact factor: 11.598
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  10 in total

1.  Assembly and structural characterization of an authentic complex between human follicle stimulating hormone and a hormone-binding ectodomain of its receptor.

Authors:  Qing R Fan; Wayne A Hendrickson
Journal:  Mol Cell Endocrinol       Date:  2006-10-12       Impact factor: 4.102

Review 2.  Novel pathways in gonadotropin receptor signaling and biased agonism.

Authors:  Alfredo Ulloa-Aguirre; Pascale Crépieux; Anne Poupon; Marie-Christine Maurel; Eric Reiter
Journal:  Rev Endocr Metab Disord       Date:  2011-12       Impact factor: 6.514

3.  Impact of the FSHB gene -211G/T polymorphism on male gonadal function.

Authors:  L Tamburino; S La Vignera; V Tomaselli; R A Condorelli; L M Mongioì; A E Calogero
Journal:  J Assist Reprod Genet       Date:  2017-03-09       Impact factor: 3.412

4.  Structures of full-length glycoprotein hormone receptor signalling complexes.

Authors:  Jia Duan; Peiyu Xu; Xi Cheng; Chunyou Mao; Tristan Croll; Xinheng He; Jingjing Shi; Xiaodong Luan; Wanchao Yin; Erli You; Qiufeng Liu; Shuyang Zhang; Hualiang Jiang; Yan Zhang; Yi Jiang; H Eric Xu
Journal:  Nature       Date:  2021-09-22       Impact factor: 49.962

5.  Hormone- and antibody-mediated activation of the thyrotropin receptor.

Authors:  Jia Duan; Peiyu Xu; Xiaodong Luan; Yujie Ji; Xinheng He; Ning Song; Qingning Yuan; Ye Jin; Xi Cheng; Hualiang Jiang; Jie Zheng; Shuyang Zhang; Yi Jiang; H Eric Xu
Journal:  Nature       Date:  2022-08-08       Impact factor: 69.504

Review 6.  Multiple facets of follicle-stimulating hormone receptor function.

Authors:  Alfredo Ulloa-Aguirre; Teresa Zariñán; Ana Ma Pasapera; Patricia Casas-González; James A Dias
Journal:  Endocrine       Date:  2008-02-02       Impact factor: 3.633

Review 7.  A functional transmembrane complex: the luteinizing hormone receptor with bound ligand and G protein.

Authors:  D Puett; Y Li; G DeMars; K Angelova; F Fanelli
Journal:  Mol Cell Endocrinol       Date:  2006-10-23       Impact factor: 4.102

8.  Expression of Luteinizing Hormone (LH) Subunit Genes in Mouse Testis.

Authors:  Hee Soo Kim; Sung-Ho Lee
Journal:  Dev Reprod       Date:  2017-09-30

Review 9.  Overview of follicle stimulating hormone and its receptors in reproduction and in stem cells and cancer stem cells.

Authors:  Swati Haldar; Himanshu Agrawal; Sarama Saha; Alex R Straughn; Partha Roy; Sham S Kakar
Journal:  Int J Biol Sci       Date:  2022-01-01       Impact factor: 6.580

10.  Variants Ala307Ala and Ser680Ser of 307 and 680 FSHr polymorphisms negatively influence on assisted reproductive techniques outcome and determine high probability of non-pregnancy in Caucasian patients.

Authors:  Belén Monge-Ochoa; Luis Montoro; Elisa Gil-Arribas; Julio Montoya; Eduardo Ruiz-Pesini; Manuel J López-Pérez; Francisco de Castro; Carmen Díez-Sánchez
Journal:  J Assist Reprod Genet       Date:  2021-08-03       Impact factor: 3.357
  10 in total

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