Literature DB >> 11898394

Molecular, structural, and cellular biology of follitropin and follitropin receptor.

James A Dias1, Brian D Cohen, Barbara Lindau-Shepard, Cheryl A Nechamen, Andrew J Peterson, Anja Schmidt.   

Abstract

Follitropin and the follitropin receptor are essential for normal gamete development in males and females. This review discusses the molecular genetics and structural and cellular biology of the follitropin/follitropin receptor system. Emphasis is placed on the human molecules when possible. The structure and regulation of the genes for the follitropin beta subunit and the follitropin receptor is discussed. Control of systemic and cellular protein levels is explained. The structural biology of each protein is described, including protein structure, motifs, and activity relationships. Finally, the follitropin/follitropin receptor signal transduction system is discussed.

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Year:  2002        PMID： 11898394     DOI： 10.1016/s0083-6729(02)64008-7

Source DB:  PubMed          Journal:  Vitam Horm        ISSN： 0083-6729            Impact factor:   3.421


  35 in total

1.  Decreased degradation of internalized follicle-stimulating hormone caused by mutation of aspartic acid 6.30(550) in a protein kinase-CK2 consensus sequence in the third intracellular loop of human follicle-stimulating hormone receptor.

Authors:  Kerri S Kluetzman; Richard M Thomas; Cheryl A Nechamen; James A Dias
Journal:  Biol Reprod       Date:  2011-01-26       Impact factor: 4.285

2.  A negative allosteric modulator demonstrates biased antagonism of the follicle stimulating hormone receptor.

Authors:  James A Dias; Béatrice Bonnet; Barbara A Weaver; Julie Watts; Kerri Kluetzman; Richard M Thomas; Sonia Poli; Vincent Mutel; Brice Campo
Journal:  Mol Cell Endocrinol       Date:  2010-12-22       Impact factor: 4.102

3.  A delayed gonadotropin-dependent and growth factor-mediated activation of the extracellular signal-regulated kinase 1/2 cascade negatively regulates aromatase expression in granulosa cells.

Authors:  Nebojsa Andric; Mario Ascoli
Journal:  Mol Endocrinol       Date:  2006-09-14

4.  Structure of human follicle-stimulating hormone in complex with its receptor.

Authors:  Qing R Fan; Wayne A Hendrickson
Journal:  Nature       Date:  2005-01-20       Impact factor: 49.962

Review 5.  Molecular pharmacology of gonadotropins.

Authors:  Robert K Campbell
Journal:  Endocrine       Date:  2005-04       Impact factor: 3.633

Review 6.  Gonadotropin receptors: role of post-translational modifications and post-transcriptional regulation.

Authors:  K M J Menon; Christine L Clouser; Anil K Nair
Journal:  Endocrine       Date:  2005-04       Impact factor: 3.633

Review 7.  Structural biology of glycoprotein hormones and their receptors.

Authors:  Qing R Fan; Wayne A Hendrickson
Journal:  Endocrine       Date:  2005-04       Impact factor: 3.633

8.  Assembly and structural characterization of an authentic complex between human follicle stimulating hormone and a hormone-binding ectodomain of its receptor.

Authors:  Qing R Fan; Wayne A Hendrickson
Journal:  Mol Cell Endocrinol       Date:  2006-10-12       Impact factor: 4.102

9.  APPL1, APPL2, Akt2 and FOXO1a interact with FSHR in a potential signaling complex.

Authors:  Cheryl A Nechamen; Richard M Thomas; James A Dias
Journal:  Mol Cell Endocrinol       Date:  2006-10-09       Impact factor: 4.102

10.  The adapter protein APPL1 links FSH receptor to inositol 1,4,5-trisphosphate production and is implicated in intracellular Ca(2+) mobilization.

Authors:  Richard M Thomas; Cheryl A Nechamen; Joseph E Mazurkiewicz; Alfredo Ulloa-Aguirre; James A Dias
Journal:  Endocrinology       Date:  2011-02-01       Impact factor: 4.736
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