Literature DB >> 1603074

The Saccharomyces cerevisiae GAM2/SIN3 protein plays a role in both activation and repression of transcription.

H Yoshimoto1, M Ohmae, I Yamashita.   

Abstract

We have cloned GAM2, which is required for transcription of STA1, a gene encoding an extracellular glucoamylase in Saccharomyces cerevisiae var. diastaticus. DNA sequence analysis revealed that GAM2 is the same gene as SIN3, known to be a general negative regulator of yeast genes. RNA blot analysis indicated that GAM2/SIN3 also acts as a positive regulator of GAM3/ADR6, which in turn is required for transcription of STA1 and ADH2. These results suggest that GAM2 regulates STA1 expression through transcriptional activation of GAM3 and indicate that GAM2/SIN3 protein is a transcriptional regulator that can play a role in both activation and repression of transcription.

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Year:  1992        PMID： 1603074     DOI： 10.1007/bf00587597

Source DB:  PubMed          Journal:  Mol Gen Genet        ISSN： 0026-8925


  21 in total

1.  Primary structure and regulation of a glucoamylase-encoding gene (STA2) in Saccharomyces diastaticus.

Authors:  M G Lambrechts; I S Pretorius; P Sollitti; J Marmur
Journal:  Gene       Date:  1991-04       Impact factor: 3.688

2.  Initiation of meiosis and sporulation in Saccharomyces cerevisiae requires a novel protein kinase homologue.

Authors:  M Yoshida; H Kawaguchi; Y Sakata; K Kominami; M Hirano; H Shima; R Akada; I Yamashita
Journal:  Mol Gen Genet       Date:  1990-04

3.  Identity of the GAM3 Gene with ADR6, Each Required for Transcription of the STA1 or ADH2 Gene in Saccharomyces cerevisiae.

Authors:  H Yoshimoto; M Ohmae; I Yamashita
Journal:  Biosci Biotechnol Biochem       Date:  1992-01       Impact factor: 2.043

4.  Both positive and negative regulators of HO transcription are required for mother-cell-specific mating-type switching in yeast.

Authors:  K Nasmyth; D Stillman; D Kipling
Journal:  Cell       Date:  1987-02-27       Impact factor: 41.582

5.  The cloning and mapping of ADR6, a gene required for sporulation and for expression of the alcohol dehydrogenase II isozyme from Saccharomyces cerevisiae.

Authors:  A K Taguchi; E T Young
Journal:  Genetics       Date:  1987-08       Impact factor: 4.562

6.  Regulation of STA1 gene expression by MAT during the life cycle of Saccharomyces cerevisiae.

Authors:  A M Dranginis
Journal:  Mol Cell Biol       Date:  1989-09       Impact factor: 4.272

7.  Gene fusion is a possible mechanism underlying the evolution of STA1.

Authors:  I Yamashita; M Nakamura; S Fukui
Journal:  J Bacteriol       Date:  1987-05       Impact factor: 3.490

8.  Functional interdependence of the yeast SNF2, SNF5, and SNF6 proteins in transcriptional activation.

Authors:  B C Laurent; M A Treitel; M Carlson
Journal:  Proc Natl Acad Sci U S A       Date:  1991-04-01       Impact factor: 11.205

9.  The yeast ADR6 gene encodes homopolymeric amino acid sequences and a potential metal-binding domain.

Authors:  P J O'Hara; H Horowitz; G Eichinger; E T Young
Journal:  Nucleic Acids Res       Date:  1988-11-11       Impact factor: 16.971

10.  Nucleotide sequence of the extracellular glucoamylase gene STA1 in the yeast Saccharomyces diastaticus.

Authors:  I Yamashita; K Suzuki; S Fukui
Journal:  J Bacteriol       Date:  1985-02       Impact factor: 3.490
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  27 in total

1.  Chromatin acetylation and remodeling at the Cis promoter during STAT5-induced transcription.

Authors:  Anne Rascle; Emma Lees
Journal:  Nucleic Acids Res       Date:  2003-12-01       Impact factor: 16.971

2.  Deacetylase activity is required for recruitment of the basal transcription machinery and transactivation by STAT5.

Authors:  Anne Rascle; James A Johnston; Bruno Amati
Journal:  Mol Cell Biol       Date:  2003-06       Impact factor: 4.272

Review 3.  Genetic regulation of phospholipid biosynthesis in Saccharomyces cerevisiae.

Authors:  M L Greenberg; J M Lopes
Journal:  Microbiol Rev       Date:  1996-03

4.  Sin3a regulates epithelial progenitor cell fate during lung development.

Authors:  Changfu Yao; Gianni Carraro; Bindu Konda; Xiangrong Guan; Takako Mizuno; Norika Chiba; Matthew Kostelny; Adrianne Kurkciyan; Gregory David; Jonathan L McQualter; Barry R Stripp
Journal:  Development       Date:  2017-06-15       Impact factor: 6.868

5.  A large protein complex containing the yeast Sin3p and Rpd3p transcriptional regulators.

Authors:  M M Kasten; S Dorland; D J Stillman
Journal:  Mol Cell Biol       Date:  1997-08       Impact factor: 4.272

6.  INO1-100: an allele of the Saccharomyces cerevisiae INO1 gene that is transcribed without the action of the positive factors encoded by the INO2, INO4, SWI1, SWI2 and SWI3 genes.

Authors:  S Swift; P McGraw
Journal:  Nucleic Acids Res       Date:  1995-04-25       Impact factor: 16.971

Review 7.  Control of meiotic gene expression in Saccharomyces cerevisiae.

Authors:  A P Mitchell
Journal:  Microbiol Rev       Date:  1994-03

8.  The yeast CCR4 protein is neither regulated by nor associated with the SPT6 and SPT10 proteins and forms a functionally distinct complex from that of the SNF/SWI transcription factors.

Authors:  C L Denis; M P Draper; H Y Liu; T Malvar; R C Vallari; W J Cook
Journal:  Genetics       Date:  1994-12       Impact factor: 4.562

9.  A pleiotropic phospholipid biosynthetic regulatory mutation in Saccharomyces cerevisiae is allelic to sin3 (sdi1, ume4, rpd1).

Authors:  K A Hudak; J M Lopes; S A Henry
Journal:  Genetics       Date:  1994-02       Impact factor: 4.562

10.  Isolation and characterization of a mutant of Saccharomyces cerevisiae with pleiotropic deficiencies in transcriptional activation and repression.

Authors:  E Lamping; J Lückl; F Paltauf; S A Henry; S D Kohlwein
Journal:  Genetics       Date:  1994-05       Impact factor: 4.562
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