Literature DB >> 16024658

Notch signaling regulates the differentiation of post-mitotic intestinal epithelial cells.

Vincent Zecchini1, Renae Domaschenz, Doug Winton, Phil Jones.   

Abstract

The intestinal epithelium comprises differentiated cells of four lineages maintained by precursor cells. As the Notch pathway controls the fate of proliferating cells in many systems, we investigated the effect of conditional expression of an activated Notch mutant in intestinal epithelium. An increase in the number of goblet cells occurs within 8 h of induction, due to an effect of Notch on post-mitotic cells, not on precursors. This observation broadens the role of Notch into controlling postmitotic differentiation and indicates that the composition of the epithelium is not solely determined by progenitor cells.

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Year:  2005        PMID： 16024658      PMCID： PMC1176006          DOI： 10.1101/gad.341705

Source DB:  PubMed          Journal:  Genes Dev        ISSN： 0890-9369            Impact factor:   11.361


  23 in total

1.  Transient Notch activation initiates an irreversible switch from neurogenesis to gliogenesis by neural crest stem cells.

Authors:  S J Morrison; S E Perez; Z Qiao; J M Verdi; C Hicks; G Weinmaster; D J Anderson
Journal:  Cell       Date:  2000-05-26       Impact factor: 41.582

2.  Contact-dependent inhibition of cortical neurite growth mediated by notch signaling.

Authors:  N Sestan; S Artavanis-Tsakonas; P Rakic
Journal:  Science       Date:  1999-10-22       Impact factor: 47.728

3.  Requirement of Math1 for secretory cell lineage commitment in the mouse intestine.

Authors:  Q Yang; N A Bermingham; M J Finegold; H Y Zoghbi
Journal:  Science       Date:  2001-12-07       Impact factor: 47.728

4.  Growth inhibition and DNA damage induced by Cre recombinase in mammalian cells.

Authors:  A Loonstra; M Vooijs; H B Beverloo; B A Allak; E van Drunen; R Kanaar; A Berns; J Jonkers
Journal:  Proc Natl Acad Sci U S A       Date:  2001-07-31       Impact factor: 11.205

5.  Cellular inheritance of a Cre-activated reporter gene to determine Paneth cell longevity in the murine small intestine.

Authors:  Heather Ireland; Carol Houghton; Louise Howard; Douglas J Winton
Journal:  Dev Dyn       Date:  2005-08       Impact factor: 3.780

6.  Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation.

Authors:  A Rangarajan; C Talora; R Okuyama; M Nicolas; C Mammucari; H Oh; J C Aster; S Krishna; D Metzger; P Chambon; L Miele; M Aguet; F Radtke; G P Dotto
Journal:  EMBO J       Date:  2001-07-02       Impact factor: 11.598

7.  A highly efficient ligand-regulated Cre recombinase mouse line shows that LoxP recombination is position dependent.

Authors:  M Vooijs; J Jonkers; A Berns
Journal:  EMBO Rep       Date:  2001-04       Impact factor: 8.807

8.  A model Notch response element detects Suppressor of Hairless-dependent molecular switch.

Authors:  M Furriols; S Bray
Journal:  Curr Biol       Date:  2001-01-09       Impact factor: 10.834

9.  Notch1 and Notch3 instructively restrict bFGF-responsive multipotent neural progenitor cells to an astroglial fate.

Authors:  K Tanigaki; F Nogaki; J Takahashi; K Tashiro; H Kurooka; T Honjo
Journal:  Neuron       Date:  2001-01       Impact factor: 17.173

10.  Neurogenin3 is differentially required for endocrine cell fate specification in the intestinal and gastric epithelium.

Authors:  Marjorie Jenny; Céline Uhl; Colette Roche; Isabelle Duluc; Valérie Guillermin; Francois Guillemot; Jan Jensen; Michèle Kedinger; Gérard Gradwohl
Journal:  EMBO J       Date:  2002-12-02       Impact factor: 11.598
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  63 in total

1.  The transcriptional corepressor MTGR1 regulates intestinal secretory lineage allocation.

Authors:  Bobak Parang; Daniel Rosenblatt; Amanda D Williams; Mary K Washington; Frank Revetta; Sarah P Short; Vishruth K Reddy; Aubrey Hunt; Noah F Shroyer; Michael E Engel; Scott W Hiebert; Christopher S Williams
Journal:  FASEB J       Date:  2014-11-14       Impact factor: 5.191

2.  Activation of two distinct Sox9-EGFP-expressing intestinal stem cell populations during crypt regeneration after irradiation.

Authors:  Laurianne Van Landeghem; M Agostina Santoro; Adrienne E Krebs; Amanda T Mah; Jeffrey J Dehmer; Adam D Gracz; Brooks P Scull; Kirk McNaughton; Scott T Magness; P Kay Lund
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2012-02-23       Impact factor: 4.052

Review 3.  Regulation of gene expression in the intestinal epithelium.

Authors:  Camilla A Richmond; David T Breault
Journal:  Prog Mol Biol Transl Sci       Date:  2010       Impact factor: 3.622

4.  Paneth Cell Multipotency Induced by Notch Activation following Injury.

Authors:  Shiyan Yu; Kevin Tong; Yanlin Zhao; Iyshwarya Balasubramanian; George S Yap; Ronaldo P Ferraris; Edward M Bonder; Michael P Verzi; Nan Gao
Journal:  Cell Stem Cell       Date:  2018-06-07       Impact factor: 24.633

5.  Inhibition of Notch signaling enhances transdifferentiation of the esophageal squamous epithelium towards a Barrett's-like metaplasia via KLF4.

Authors:  Maria E Vega; Véronique Giroux; Mitsuteru Natsuizaka; Mingen Liu; Andres J Klein-Szanto; Douglas B Stairs; Hiroshi Nakagawa; Kenneth K Wang; Timothy C Wang; John P Lynch; Anil K Rustgi
Journal:  Cell Cycle       Date:  2014       Impact factor: 4.534

Review 6.  RNA regulons are essential in intestinal homeostasis.

Authors:  Louis R Parham; Patrick A Williams; Priya Chatterji; Kelly A Whelan; Kathryn E Hamilton
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2018-12-06       Impact factor: 4.052

Review 7.  The pathogenic role of Notch activation in podocytes.

Authors:  Thiruvur Niranjan; Mariana Murea; Katalin Susztak
Journal:  Nephron Exp Nephrol       Date:  2009-03-17

Review 8.  GCC signaling in colorectal cancer: Is colorectal cancer a paracrine deficiency syndrome?

Authors:  P Li; J E Lin; G P Marszlowicz; M A Valentino; C Chang; S Schulz; G M Pitari; Scott A Waldman
Journal:  Drug News Perspect       Date:  2009 Jul-Aug

9.  Down-regulation of the Notch pathway mediated by a gamma-secretase inhibitor induces anti-tumour effects in mouse models of T-cell leukaemia.

Authors:  J Tammam; C Ware; C Efferson; J O'Neil; S Rao; X Qu; J Gorenstein; M Angagaw; H Kim; C Kenific; K Kunii; K J Leach; G Nikov; J Zhao; X Dai; J Hardwick; M Scott; C Winter; L Bristow; C Elbi; J F Reilly; T Look; G Draetta; Lht Van der Ploeg; N E Kohl; P R Strack; P K Majumder
Journal:  Br J Pharmacol       Date:  2009-09-23       Impact factor: 8.739

10.  Niche-independent high-purity cultures of Lgr5+ intestinal stem cells and their progeny.

Authors:  Xiaolei Yin; Henner F Farin; Johan H van Es; Hans Clevers; Robert Langer; Jeffrey M Karp
Journal:  Nat Methods       Date:  2013-12-01       Impact factor: 28.547
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