| Literature DB >> 16023742 |
Ursula Felderhoff-Mueser1, Oliver I Schmidt, Andreas Oberholzer, Christoph Bührer, Philip F Stahel.
Abstract
Interleukin (IL)-18 is a potent inflammatory cytokine of the IL-1 family. It is synthesized as an inactive precursor (pro-IL-18), which is cleaved into its functionally active form by caspase-1. Resident cells of the CNS express IL-18 and caspase-1 constitutively, thus providing a local IL-18-dependent immune response. Recent studies have highlighted a crucial role for IL-18 in mediating neuroinflammation and neurodegeneration in the CNS under pathological conditions, such as bacterial and viral infection, autoimmune demyelinating disease, and hypoxic-ischemic, hyperoxic and traumatic brain injuries. This review provides a synopsis of the current knowledge of IL-18-dependent mechanisms of action during acute neurodegeneration in immature and adult brains.Entities:
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Year: 2005 PMID： 16023742 DOI： 10.1016/j.tins.2005.06.008
Source DB: PubMed Journal: Trends Neurosci ISSN： 0166-2236 Impact factor: 13.837