Literature DB >> 16012805

A model of intracellular transport of particles in an axon.

Avner Friedman1, Gheorghe Craciun.   

Abstract

In this paper we develop a model of intracellular transport of cell organelles and vesicles along the axon of a nerve cell. These particles are moving alternately by processive motion along a microtubule with the aid of motor proteins, and by diffusion. The model involves a degenerate system of diffusion equations. We prove a maximum principle and establish existence and behavior of a unique solution. Numerical results show how the transportation of mass depends on the relevant parameters of the model.

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Year:  2005        PMID: 16012805     DOI: 10.1007/s00285-004-0285-3

Source DB:  PubMed          Journal:  J Math Biol        ISSN: 0303-6812            Impact factor:   2.259


  13 in total

1.  Overexpression of neurofilament subunit M accelerates axonal transport of neurofilaments.

Authors:  Z Xu; V W Tung
Journal:  Brain Res       Date:  2000-06-02       Impact factor: 3.252

2.  Rapid intermittent movement of axonal neurofilaments observed by fluorescence photobleaching.

Authors:  L Wang; A Brown
Journal:  Mol Biol Cell       Date:  2001-10       Impact factor: 4.138

3.  Theoretical analysis of radioactivity profiles during fast axonal transport: effects of deposition and turnover.

Authors:  M C Reed; J J Blum
Journal:  Cell Motil Cytoskeleton       Date:  1986

4.  Theoretical analysis of lipid transport in sciatic nerve.

Authors:  J J Blum; D D Carr; M C Reed
Journal:  Biochim Biophys Acta       Date:  1992-05-08

5.  Monte Carlo analysis of obstructed diffusion in three dimensions: application to molecular diffusion in organelles.

Authors:  B P Olveczky; A S Verkman
Journal:  Biophys J       Date:  1998-05       Impact factor: 4.033

6.  Movement of organelles along filaments dissociated from the axoplasm of the squid giant axon.

Authors:  R D Vale; B J Schnapp; T S Reese; M P Sheetz
Journal:  Cell       Date:  1985-02       Impact factor: 41.582

7.  A theoretical approach to the analysis of axonal transport.

Authors:  S I Rubinow; J J Blum
Journal:  Biophys J       Date:  1980-04       Impact factor: 4.033

8.  A quantitative analysis of isotope concentration profiles and rapid transport velocities in the C-fibers of the garfish olfactory nerve.

Authors:  G W Gross; L M Beidler
Journal:  J Neurobiol       Date:  1975-03

9.  Identification of a novel force-generating protein, kinesin, involved in microtubule-based motility.

Authors:  R D Vale; T S Reese; M P Sheetz
Journal:  Cell       Date:  1985-08       Impact factor: 41.582

10.  Translational diffusion of macromolecule-sized solutes in cytoplasm and nucleus.

Authors:  O Seksek; J Biwersi; A S Verkman
Journal:  J Cell Biol       Date:  1997-07-14       Impact factor: 10.539

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  11 in total

1.  Mathematical modeling and parameter estimation of axonal cargo transport.

Authors:  Kouroush Sadegh Zadeh; Sameer B Shah
Journal:  J Comput Neurosci       Date:  2010-04-21       Impact factor: 1.621

2.  Modeling of toxin-antibody interaction and toxin transport toward the endoplasmic reticulum.

Authors:  Vladas Skakauskas; Pranas Katauskis
Journal:  J Biol Phys       Date:  2015-08-26       Impact factor: 1.365

3.  A dynamical system model of neurofilament transport in axons.

Authors:  Gheorghe Craciun; Anthony Brown; Avner Friedman
Journal:  J Theor Biol       Date:  2005-06-21       Impact factor: 2.691

4.  Metastable behavior in Markov processes with internal states.

Authors:  Jay Newby; Jon Chapman
Journal:  J Math Biol       Date:  2013-09-01       Impact factor: 2.259

5.  Model of neurotransmitter fast transport in axon terminal of presynaptic neuron.

Authors:  Andrzej Bielecki; Piotr Kalita
Journal:  J Math Biol       Date:  2007-10-09       Impact factor: 2.259

6.  A stochastic model that explains axonal organelle pileups induced by a reduction of molecular motors.

Authors:  Xiulan Lai; Anthony Brown; Chuan Xue
Journal:  J R Soc Interface       Date:  2018-11-28       Impact factor: 4.118

Review 7.  Stochastic Hybrid Systems in Cellular Neuroscience.

Authors:  Paul C Bressloff; James N Maclaurin
Journal:  J Math Neurosci       Date:  2018-08-22       Impact factor: 1.300

8.  Modeling neutralization of Shiga 2 toxin by A-and B-subunit-specific human monoclonal antibodies.

Authors:  Vladas Skakauskas; Pranas Katauskis
Journal:  J Biol Phys       Date:  2016-05-07       Impact factor: 1.365

9.  Predictive models for pressure-driven fluid infusions into brain parenchyma.

Authors:  Raghu Raghavan; Martin Brady
Journal:  Phys Med Biol       Date:  2011-09-02       Impact factor: 3.609

10.  Deep learning of material transport in complex neurite networks.

Authors:  Angran Li; Amir Barati Farimani; Yongjie Jessica Zhang
Journal:  Sci Rep       Date:  2021-05-28       Impact factor: 4.379

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