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Literature DB >> 16011362

Toward cocaine esterase therapeutics.

Claude J Rogers¹, Jenny M Mee, Gunnar F Kaufmann, Tobin J Dickerson, Kim D Janda.

Abstract

Cocaine is among the most reinforcing of all drugs of abuse, yet no effective pharmacotherapy is available. Herein, we report the development and characterization of phage-displayed cocaine esterases with pharmacologically relevant kinetic parameters (kcat/Km approximately 104 M-1 s-1).

Entities: Chemical Gene

Mesh：

Substances：

Year: 2005 PMID： 16011362 PMCID： PMC1352337 DOI： 10.1021/ja053086a

Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419

30 in total

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9 in total

Review 1. Accelerating cocaine metabolism as an approach to the treatment of cocaine abuse and toxicity.

Authors: Charles W Schindler; Steven R Goldberg
Journal: Future Med Chem Date: 2012-02 Impact factor: 3.808

2. Unexpected acetylcholinesterase activity of cocaine esterases.

Authors: Claude J Rogers; Lisa M Eubanks; Tobin J Dickerson; Kim D Janda
Journal: J Am Chem Soc Date: 2006-12-06 Impact factor: 15.419

3. Structural analysis of thermostabilizing mutations of cocaine esterase.

Authors: Diwahar Narasimhan; Mark R Nance; Daquan Gao; Mei-Chuan Ko; Joanne Macdonald; Patricia Tamburi; Dan Yoon; Donald M Landry; James H Woods; Chang-Guo Zhan; John J G Tesmer; Roger K Sunahara
Journal: Protein Eng Des Sel Date: 2010-04-30 Impact factor: 1.650