Literature DB >> 16010347

Cucurbitacins and cucurbitane glycosides: structures and biological activities.

Jian Chao Chen1, Ming Hua Chiu, Rui Lin Nie, Geoffrey A Cordell, Samuel X Qiu.   

Abstract

The natural cucurbitacins constitute a group of triterpenoid substances which are well-known for their bitterness and toxicity. Structurally, they are characterized by the tetracyclic cucurbitane nucleus skeleton, namely, 19-(10-->9beta)-abeo-10alpha-lanost-5-ene (also known as 9beta-methyl-19-norlanosta-5-ene), with a variety of oxygen substitutions at different positions. According to the characteristics of their structures, cucurbitacins are divided into twelve categories. The biological effects of the cucurbitacins are also covered.

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Year:  2005        PMID： 16010347     DOI： 10.1039/b418841c

Source DB:  PubMed          Journal:  Nat Prod Rep        ISSN： 0265-0568            Impact factor:   13.423


  123 in total

1.  The natural product cucurbitacin E inhibits depolymerization of actin filaments.

Authors:  Pia M Sörensen; Roxana E Iacob; Marco Fritzsche; John R Engen; William M Brieher; Guillaume Charras; Ulrike S Eggert
Journal:  ACS Chem Biol       Date:  2012-07-09       Impact factor: 5.100

Review 2.  Targeting Cancer Metabolism and Current Anti-Cancer Drugs.

Authors:  Witchuda Sukjoi; Jarunya Ngamkham; Paul V Attwood; Sarawut Jitrapakdee
Journal:  Adv Exp Med Biol       Date:  2021       Impact factor: 2.622

3.  Genomic and coexpression analyses predict multiple genes involved in triterpene saponin biosynthesis in Medicago truncatula.

Authors:  Marina A Naoumkina; Luzia V Modolo; David V Huhman; Ewa Urbanczyk-Wochniak; Yuhong Tang; Lloyd W Sumner; Richard A Dixon
Journal:  Plant Cell       Date:  2010-03-26       Impact factor: 11.277

4.  Whole-genome sequencing provides insights into the genetic diversity and domestication of bitter gourd (Momordica spp.).

Authors:  Junjie Cui; Yan Yang; Shaobo Luo; Le Wang; Rukui Huang; Qingfang Wen; Xiaoxia Han; Nansheng Miao; Jiaowen Cheng; Ziji Liu; Changyuan Zhang; Chengcheng Feng; Haisheng Zhu; Jianwen Su; Xinjian Wan; Fang Hu; Yu Niu; Xiaoming Zheng; Yulan Yang; Dai Shan; Zhensheng Dong; Weiming He; Narinder P S Dhillon; Kailin Hu
Journal:  Hortic Res       Date:  2020-06-01       Impact factor: 6.793

5.  Identification of steroid-like natural products as antiplasmodial agents by 2D and 3D similarity-based virtual screening.

Authors:  Elumalai Pavadai; Gurminder Kaur; Sergio Wittlin; Kelly Chibale
Journal:  Medchemcomm       Date:  2017-03-22       Impact factor: 3.597

6.  Cucurbitacin B, a novel in vivo potentiator of gemcitabine with low toxicity in the treatment of pancreatic cancer.

Authors:  Gabriela B Iwanski; Dhong H Lee; Shlomit En-Gal; Ngan B Doan; Brandon Castor; Marco Vogt; Melvin Toh; Carsten Bokemeyer; Jonathan W Said; Nils H Thoennissen; H Phillip Koeffler
Journal:  Br J Pharmacol       Date:  2010-06       Impact factor: 8.739

7.  Growth inhibitory effect of Cucurbitacin E on breast cancer cells.

Authors:  Tian Lan; Linling Wang; Qian Xu; Weiguo Liu; Hongchuan Jin; Weimin Mao; Xian Wang; Xiaojia Wang
Journal:  Int J Clin Exp Pathol       Date:  2013-08-15

Review 8.  Plant-derived triterpenoids and analogues as antitumor and anti-HIV agents.

Authors:  Reen-Yen Kuo; Keduo Qian; Susan L Morris-Natschke; Kuo-Hsiung Lee
Journal:  Nat Prod Rep       Date:  2009-08-13       Impact factor: 13.423

9.  Activated kRas protects colon cancer cells from cucurbitacin-induced apoptosis: the role of p53 and p21.

Authors:  José M Escandell; Pawan Kaler; M Carmen Recio; Takehiko Sasazuki; Senji Shirasawa; Leonard Augenlicht; José-Luis Ríos; Lidija Klampfer
Journal:  Biochem Pharmacol       Date:  2008-05-08       Impact factor: 5.858

10.  Cucurbitacin D induces growth inhibition, cell cycle arrest, and apoptosis in human endometrial and ovarian cancer cells.

Authors:  Terukazu Ishii; Naoko Kira; Toshie Yoshida; Hisashi Narahara
Journal:  Tumour Biol       Date:  2012-11-14
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