Literature DB >> 16007519

Subtherapeutic ocular penetration of caspofungin and associated treatment failure in Candida albicans endophthalmitis.

G M Gauthier1, T M Nork, R Prince, D Andes.   

Abstract

Candida endophthalmitis represents the most serious ocular complication of candidemia. The pharmacokinetics and pharmacodynamics of fluconazole, amphotericin B, and flucytosine are fairly well established in endophthalmitis therapy. There remains a paucity of clinical data regarding the utility of new antimycotic agents in the treatment of fungal chorioretinitis and endophthalmitis. We report a case of clinical failure of caspofungin in the management of Candida albicans endophthalmitis associated with poor vitreous penetration.

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Year:  2005        PMID： 16007519     DOI： 10.1086/431761

Source DB:  PubMed          Journal:  Clin Infect Dis        ISSN： 1058-4838            Impact factor:   9.079


  30 in total

1.  Evaluating retinal toxicity of intravitreal caspofungin in the mouse eye.

Authors:  Deb K Mojumder; Francis A Concepcion; Shil K Patel; Andrew J Barkmeier; Petros E Carvounis; John H Wilson; Eric R Holz; Theodore G Wensel
Journal:  Invest Ophthalmol Vis Sci       Date:  2010-05-26       Impact factor: 4.799

Review 2.  Risk of Fungal Endophthalmitis Associated with Cataract Surgery: A Mini-Review.

Authors:  Tonya C Smith; Russell J Benefield; Jong Hun Kim
Journal:  Mycopathologia       Date:  2015-08-29       Impact factor: 2.574

3.  Efficacy and Pharmacokinetics of Fosmanogepix (APX001) in the Treatment of Candida Endophthalmitis and Hematogenous Meningoencephalitis in Nonneutropenic Rabbits.

Authors:  Ruta Petraitiene; Vidmantas Petraitis; Bo Bo Win Maung; Robert S Mansbach; Michael R Hodges; Malcolm A Finkelman; Karen Joy Shaw; Thomas J Walsh
Journal:  Antimicrob Agents Chemother       Date:  2021-02-17       Impact factor: 5.191

4.  Efficacy of micafungin for the treatment of candidemia.

Authors:  D Andes; N Safdar
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2005-10       Impact factor: 3.267

Review 5.  Treatment principles for the management of mold infections.

Authors:  Dimitrios P Kontoyiannis; Russell E Lewis
Journal:  Cold Spring Harb Perspect Med       Date:  2014-11-06       Impact factor: 6.915

Review 6.  Treatment principles for Candida and Cryptococcus.

Authors:  Laura C Whitney; Tihana Bicanic
Journal:  Cold Spring Harb Perspect Med       Date:  2014-11-10       Impact factor: 6.915

7.  Penetration of topically administered 0.5-percent caspofungin eye drops into human aqueous humor.

Authors:  Chin Fen Neoh; Lok Leung; Anant Misra; Rasik B Vajpayee; Geoffrey E Davies; Robert O Fullinfaw; Kay Stewart; David C M Kong
Journal:  Antimicrob Agents Chemother       Date:  2011-01-24       Impact factor: 5.191

8.  Endophthalmitis: Pathogenesis, clinical presentation, management, and perspectives.

Authors:  M Kernt; A Kampik
Journal:  Clin Ophthalmol       Date:  2010-03-24

9.  Intraocular penetration of intravenous micafungin in inflamed human eyes.

Authors:  Kiyofumi Mochizuki; Akira Sawada; Shinsuke Suemori; Hideaki Kawakami; Yoshiaki Niwa; Yuji Kondo; Kiyofumi Ohkusu; Noriaki Yamada; Shinji Ogura; Takashi Yaguchi; Kazuko Nishimura; Satoshi Kishino
Journal:  Antimicrob Agents Chemother       Date:  2013-05-20       Impact factor: 5.191

10.  Fungal echinocandin resistance.

Authors:  Louise A Walker; Neil A R Gow; Carol A Munro
Journal:  Fungal Genet Biol       Date:  2009-09-19       Impact factor: 3.495
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