AIM/HYPOTHESIS: Evidence suggests that postprandial hyperglycaemia may be a cardiovascular risk factor in diabetes. Oxidative stress and inflammation are involved in the pathogenesis of diabetic complications and previous studies have shown increased oxidative stress and inflammation in the postprandial phase in diabetic patients. The aim of the present study was to evaluate whether controlling postprandial hyperglycaemia with S21403 (mitiglinide) is accompanied by a reduced generation of oxidative stress and inflammation. SUBJECTS AND METHODS: Forty type 2 diabetic patients participated in the study. Two different breakfast-tests were performed in each patient, with placebo or S21403. Plasma nitrotyrosine, plasma malondialdehyde (MDA), oxidised LDL (oxLDL), plasma total radical-trapping antioxidant parameter (TRAP), IL-6, IL-18, TNF-alpha, plasma glucose and insulin were measured. RESULTS: After the administration of S21403, 40 mg, a rapid stimulation of insulin secretion was observed, accompanied by a reduction of postprandial hyperglycaemia. With S21403, a significant decrease of either nitrotyrosine, MDA and oxLDL levels, and a preservation of plasma TRAP compared with placebo was found. Significant decreases of IL-6, IL-18 and TNF-alpha were also observed with S21403 compared with placebo. CONCLUSIONS/ INTERPRETATION: This study shows that controlling postprandial hyperglycaemia with S21403 significantly improves the cluster of oxidative stress and inflammation markers that are increased in the postprandial state in diabetic patients.
RCT Entities:
AIM/HYPOTHESIS: Evidence suggests that postprandial hyperglycaemia may be a cardiovascular risk factor in diabetes. Oxidative stress and inflammation are involved in the pathogenesis of diabetic complications and previous studies have shown increased oxidative stress and inflammation in the postprandial phase in diabeticpatients. The aim of the present study was to evaluate whether controlling postprandial hyperglycaemia with S21403 (mitiglinide) is accompanied by a reduced generation of oxidative stress and inflammation. SUBJECTS AND METHODS: Forty type 2 diabeticpatients participated in the study. Two different breakfast-tests were performed in each patient, with placebo or S21403. Plasma nitrotyrosine, plasma malondialdehyde (MDA), oxidised LDL (oxLDL), plasma total radical-trapping antioxidant parameter (TRAP), IL-6, IL-18, TNF-alpha, plasma glucose and insulin were measured. RESULTS: After the administration of S21403, 40 mg, a rapid stimulation of insulin secretion was observed, accompanied by a reduction of postprandial hyperglycaemia. With S21403, a significant decrease of either nitrotyrosine, MDA and oxLDL levels, and a preservation of plasma TRAP compared with placebo was found. Significant decreases of IL-6, IL-18 and TNF-alpha were also observed with S21403 compared with placebo. CONCLUSIONS/ INTERPRETATION: This study shows that controlling postprandial hyperglycaemia with S21403 significantly improves the cluster of oxidative stress and inflammation markers that are increased in the postprandial state in diabeticpatients.
Authors: A Ceriello; N Bortolotti; E Motz; C Pieri; M Marra; L Tonutti; S Lizzio; F Feletto; B Catone; C Taboga Journal: Metabolism Date: 1999-12 Impact factor: 8.694
Authors: Antonio Ceriello; Ludovica Piconi; Lisa Quagliaro; Yan Wang; Catherine A Schnabel; James A Ruggles; Maurice A Gloster; David G Maggs; Christian Weyer Journal: Diabetes Care Date: 2005-03 Impact factor: 19.112
Authors: Francesco Nappo; Katherine Esposito; Michele Cioffi; Giovanni Giugliano; Anna Maria Molinari; Giuseppe Paolisso; Raffaele Marfella; Dario Giugliano Journal: J Am Coll Cardiol Date: 2002-04-03 Impact factor: 24.094
Authors: G Rudofsky; P Reismann; S Schiekofer; D Petrov; M von Eynatten; P M Humpert; B Isermann; C Müller-Hoff; T-P Thai; S Lichtenstein; U Bärtsch; A Hamann; P Nawroth; A Bierhaus Journal: Horm Metab Res Date: 2004-09 Impact factor: 2.936
Authors: A Ceriello; N Bortolotti; E Motz; A Crescentini; S Lizzio; A Russo; L Tonutti; C Taboga Journal: Diabetes Care Date: 1998-09 Impact factor: 19.112
Authors: Y Mori; K Ojima; Y Fuujimori; Y Fujimori; I Aoyagi; H Kusama; Y Yamazaki; M Kojima; S Kojima; N Shibata; Y Itoh; N Tajima Journal: Endocrine Date: 2006-04 Impact factor: 3.633
Authors: R Mallone; S I Mannering; B M Brooks-Worrell; I Durinovic-Belló; C M Cilio; F S Wong; N C Schloot Journal: Clin Exp Immunol Date: 2010-10-05 Impact factor: 4.330
Authors: P J Beisswenger; W V Brown; A Ceriello; N A Le; R B Goldberg; J P Cooke; D C Robbins; S Sarwat; H Yuan; C A Jones; M H Tan Journal: Diabet Med Date: 2011-09 Impact factor: 4.359