OBJECTIVE: The objective of this work was to ascertain if sensory gating can be demonstrated within the human medial temporal lobe. METHODS: Eight patients with intractable epilepsy with depth electrodes implanted in the medial temporal lobe for pre-surgery evaluation underwent evoked response recording to auditory paired-stimuli (S1-S2). Each of the eight subjects had a diagnosis of left medial temporal lobe epilepsy (MTLE). RESULTS: Data from the non-focal right hippocampi revealed a large negative response on S1 (starting at about 190 ms and lasting for approximately 300 ms from stimulus onset). Rhinal region recordings revealed a positive response (starting at about 240 ms with a rapid incline, followed by a long-lasting decline). A significant attenuation of both responses to S2 stimuli was observed. CONCLUSIONS: Data are suggestive of an involvement of the human medial temporal lobe in the processing of simple auditory information which occurs in a time frame later than the neocortical auditory evoked components. The exact role of these anatomical structures in the sensory gating process remains to be defined. SIGNIFICANCE: This study provides the first evidence of an activation of the rhinal cortex after simple auditory stimulation and provides new evidence that the activation of the medial temporal lobe structures occurs at a later stage than that of the neocortex.
OBJECTIVE: The objective of this work was to ascertain if sensory gating can be demonstrated within the human medial temporal lobe. METHODS: Eight patients with intractable epilepsy with depth electrodes implanted in the medial temporal lobe for pre-surgery evaluation underwent evoked response recording to auditory paired-stimuli (S1-S2). Each of the eight subjects had a diagnosis of left medial temporal lobe epilepsy (MTLE). RESULTS: Data from the non-focal right hippocampi revealed a large negative response on S1 (starting at about 190 ms and lasting for approximately 300 ms from stimulus onset). Rhinal region recordings revealed a positive response (starting at about 240 ms with a rapid incline, followed by a long-lasting decline). A significant attenuation of both responses to S2 stimuli was observed. CONCLUSIONS: Data are suggestive of an involvement of the human medial temporal lobe in the processing of simple auditory information which occurs in a time frame later than the neocortical auditory evoked components. The exact role of these anatomical structures in the sensory gating process remains to be defined. SIGNIFICANCE: This study provides the first evidence of an activation of the rhinal cortex after simple auditory stimulation and provides new evidence that the activation of the medial temporal lobe structures occurs at a later stage than that of the neocortex.
Authors: Martin Kurthen; Peter Trautner; Timm Rosburg; Thomas Grunwald; Thomas Dietl; Kai-Uwe Kühn; Carlo Schaller; Christian E Elger; Horst Urbach; Kost Elisevich; Nash N Boutros Journal: Psychiatry Res Date: 2007-05-21 Impact factor: 3.222
Authors: Nash N Boutros; Klevest Gjini; Simon B Eickhoff; Horst Urbach; Mark E Pflieger Journal: Clin Neurophysiol Date: 2012-11-04 Impact factor: 3.708
Authors: Sven Vanneste; Mark Plazier; Jan Ost; Elsa van der Loo; Paul Van de Heyning; Dirk De Ridder Journal: Exp Brain Res Date: 2010-02-26 Impact factor: 1.972
Authors: Robert J Thoma; Faith M Hanlon; Helen Petropoulos; Gregory A Miller; Sandra N Moses; Ashley Smith; Lauren Parks; S Laura Lundy; Natalie M Sanchez; Aaron Jones; Mingxiong Huang; Michael P Weisend; Jose M Cañive Journal: Psychophysiology Date: 2008-09-24 Impact factor: 4.016